142279-40-1

142279-40-1 structure

Name: Shizukaol B
Chemical Name: shizukaol B
CAS Number: 142279-40-1
Molecular Formula: C₄₀H₄₄O₁₃
Molecular Weight: 732.77000
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-05-08 05:51:05
Modify Date: 2024-01-02 12:07:40
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression[1].

Name	shizukaol B

Description	Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2 iNOS IL-1β
In Vitro	Shizukaol B (25 μM; 0-60 min) 抑制 LPS (1 μg/mL; 0-60 min) 介导的 c-Jun N 末端激酶 1/2 (JNK) 激活，不影响 ERK1/2 或 p38 磷酸化[1]。 Shizukaol B (12.5-50 μM; 4 h) 抑制 LPS 诱导 (1 μg/mL; 24 h) 的 NO 生成，抑制 iNOS 和 COX-2 的表达[1]。
References	[1]. Pan LL, et al. Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomed Pharmacother. 2017 Apr;88:878-884.