Silodosin-d4
Modify Date: 2024-01-13 15:08:45
Silodosin-d4 structure
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Common Name | Silodosin-d4 | ||
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| CAS Number | 1426173-86-5 | Molecular Weight | 499.559 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 601.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C25H28D4F3N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 317.5±31.5 °C | |
Use of Silodosin-d4Silodosin-d4 (KAD 3213-d4) is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH[1][3]. |
| Name | Silodosin-d4 |
|---|---|
| Synonym | More Synonyms |
| Description | Silodosin-d4 (KAD 3213-d4) is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH[1][3]. |
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| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 601.4±55.0 °C at 760 mmHg |
| Molecular Formula | C25H28D4F3N3O4 |
| Molecular Weight | 499.559 |
| Flash Point | 317.5±31.5 °C |
| Exact Mass | 499.259613 |
| LogP | 2.52 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.552 |
| SILODOSIN-D4 |
| 1H-Indole-7-carboxamide, 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl-1,1,2,2-d4]amino]propyl]- |
| 1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy](2H4)ethyl}amino)propyl]-7-indolinecarboxamide |