PI4KIIIbeta-IN-11

Modify Date: 2024-01-19 17:01:00

PI4KIIIbeta-IN-11 structure	Common Name	PI4KIIIbeta-IN-11
	CAS Number	2365241-79-6	Molecular Weight	581.71
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₃₉N₇O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PI4KIIIbeta-IN-11

PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC50 value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum[1][2].

Name	PI4KIIIbeta-IN-11

Description	PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC50 value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> PI3K/Akt/mTOR >> PI4K
Target	PI4KIIIβ:9.1 (pIC50)
In Vitro	PI4KIIIβ may be a relevant target protein for inhibition of Hedgehog signaling, and regulates trafficking from the Golgi system to the plasma membrane[1]. PI4KIIIbeta-IN-11 (compound 22) (0.5 μM; 0-45 min) shows metabolic stability in human microsomes, with the intrinsic clearance of 33.7 mL/min/g[2].
In Vivo	PI4KIIIbeta-IN-11 (compound 22) (1 mg/kg; i.v.; last over 1 h) displays a low spleen concentration in rats[2]. Animal Model: Male Wistar Han Rats[2] Dosage: 1 mg/kg Administration: Intravenous injection, formulated in 2% DMSO in Kleptose (aq, 10% w/v); over 1 hour; euthanised at 12 h Result: Showed a low concentration in spleen of 5.54 ng/g.
References	[1]. Kremer L, et al. Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angew Chem Int Ed Engl. 2019 Nov 11;58(46):16617-16628. [2]. Barton Nicholas Paul, et al. Preparation of pyrazolopyrimidinamines derivatives as PI4kIII-beta inhibitors: World Intellectual Property Organization, WO2019141694. 2019-07-25.

Molecular Formula	C₃₃H₃₉N₇O₃
Molecular Weight	581.71