AKI603
Modify Date: 2023-01-19 12:54:01
AKI603 structure
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Common Name | AKI603 | ||
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| CAS Number | 1432515-73-5 | Molecular Weight | 409.454 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H23N9O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AKI603A novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration. |
| Name | AKI-603 |
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| Description | A novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration. |
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| References | References 1. Zheng FM, et al. Mol Cancer Ther. 2014 Aug;13(8):1991-2003. 2. Long ZJ, et al. Int J Oncol. 2015;46(6):2488-96. 3. Wang LX, et al. Sci Rep. 2016 Nov 8;6:35533. View Related Products by Target Aurora Kinase |
| Molecular Formula | C19H23N9O2 |
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| Molecular Weight | 409.454 |