Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)

Modify Date: 2024-01-04 14:58:49

Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid) Structure
Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid) structure
 Common Name Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)
CAS Number 143313-51-3 Molecular Weight 492.522
Density 1.3±0.1 g/cm3 Boiling Point 937.7±65.0 °C at 760 mmHg
Molecular Formula C23H32N4O8 Melting Point N/A
MSDS N/A Flash Point 520.9±34.3 °C

 Use of Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)


Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1].

 Names

Name ac-yvad-cho
Synonym More Synonyms

  Biological Activity

Description Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1].
Related Catalog
Target

IL-1β:3 nM (Ki)

IL-1β:0.76 nM (Ki)

In Vitro Ac-YVAD-CHO inhibits IL-1β in a dose-dependent manner, with mouse and human IC50 values of 2.5 and 0.7 μM. Ac-YVAD-CHO (0.01~100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS in a dose-related manner[1].
In Vivo Ac-YVAD-CHO (10 mg/kg; i.p.; 1 hour) is absorbed from the peritoneal cavity, as well as cleared from the blood rapidly[1]. Ac-YVAD-CHO (50 mg/kg; i.p.; 1 hour) drops precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection[1]. Ac-YVAD-CHO (30 mg/kg; i.p.; 6 hours) suppresses IL-1β levels[1]. Animal Model: CD1 female mice Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: I.p.; 1 hour Result: Absorbed from the peritoneal cavity, as well as cleared from the blood rapidly. Animal Model: CD1 female mice Dosage: 50 mg/kg (Pharmacokinetic Analysis) Administration: I.p.; 1 hour Result: Dropped precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection. Animal Model: P. acnes-sensitized mice Dosage: 30 mg/kg Administration: I.p.; 6 hours Result: Suppressed IL-1β levels.
References

[1]. Fletcher DS, et al. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res. 1995;15(3):243-248.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 937.7±65.0 °C at 760 mmHg
Molecular Formula C23H32N4O8
Molecular Weight 492.522
Flash Point 520.9±34.3 °C
Exact Mass 492.222015
PSA 191.00000
LogP 0.79
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.552
Storage condition −20°C

 Safety Information

WGK Germany 3

 Synonyms

pase inhibitor i
acetyl-yvad-aldehyde
ice inhibitor
ac-yvad-aldehyde
N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-alaninamide
L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-((1S)-2-carboxy-1-formylethyl)-
tyr-val-ala-asp-cho
N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-alaninamide
yvad-cho
L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-
ice inhibitor i
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Chemsrc provides CAS#:143313-51-3 MSDS, density, melting point, boiling point, structure, etc. Its name is Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)>> amp version: Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)

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