Eletriptan

Modify Date: 2024-01-02 18:26:48

Eletriptan structure	Common Name	Eletriptan
	CAS Number	143322-58-1	Molecular Weight	382.519
	Density	1.2±0.1 g/cm3	Boiling Point	613.4±55.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₆N₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	324.8±31.5 °C

Use of Eletriptan

Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[1].

Name	eletriptan
Synonym	More Synonyms

Description	Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[1].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1B Receptor:8.0 (pKi) 5-HT1D Receptor:8.9 (pKi)
In Vivo	Eletriptan (10, 30, 100, 300 and 1000 µg/kg; i.v.) reduces total carotid blood flow in anaesthetised pigs by selectively reducing carotid arteriovenous anastomotic blood flow and increasing nutrient blood flow within the carotid vascular bed[2].
References	[1]. McCormack PL, Keating GM. Eletriptan: a review of its use in the acute treatment of migraine. Drugs. 2006;66(8):1129-49. [2]. Willems E, et al. Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug;358(2):212-9.

Density	1.2±0.1 g/cm3
Boiling Point	613.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₆N₂O₂S
Molecular Weight	382.519
Flash Point	324.8±31.5 °C
Exact Mass	382.171509
PSA	61.55000
LogP	3.08
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.634
Storage condition	Hygroscopic, Refrigerator, Under Inert Atmosphere

Precursor 8
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DownStream 1
CAS#:177834-92-3 Eletriptan HBr