Emtricitabine

Modify Date: 2024-01-02 03:17:39

Emtricitabine Structure
Emtricitabine structure
 Common Name Emtricitabine
CAS Number 143491-57-0 Molecular Weight 247.247
Density 1.8±0.1 g/cm3 Boiling Point 443.3±55.0 °C at 760 mmHg
Molecular Formula C8H10FN3O3S Melting Point 136-140°C
MSDS N/A Flash Point 221.9±31.5 °C

 Use of Emtricitabine


Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 µM in PBMC cell. It is an antiviral drug for the treatment of HIV infection.

 Names

Name Emtricitabine
Synonym More Synonyms

 Emtricitabine Biological Activity

Description Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 µM in PBMC cell. It is an antiviral drug for the treatment of HIV infection.
Related Catalog
Target

EC50: 0.01 µM (NRTI, PBMC), 0.026 µM (NRTI, HeLa cell)[1]

In Vitro Emtricitabine has in vitro activity against both laboratory strains of HIV-1 and HIV-2 and clinical isolates of HIV-1. The 50% effective concentration (EC50) ranges from 0.002 to 1.5 µ mol/L, depending on the viral isolate and cell line used. Emtricitabine demonstrates in vitro synergy with zidovudine and stavudine and additive in vitro activity when combines with zalcitabine or didanosine[1].
In Vivo Reproductive and developmental toxicology studies are conducted with emtricitabine. Oral doses up to 1000 mg/kg/day provided daily area under the curve (AUC0→24) exposure to pregnant animals approximately 60- (mice) to 120-fold (rabbits) higher than that in humans at the recommended dose of 200 mg given once per day. In a mouse fertility study, emtricitabine had no effect on fertility, sperm count, or early embryonic development. There is no increased incidence of malformations in mouse and rabbit embryofetal toxicology studies. The development and fertility of F1 progeny are unaffected by emtricitabine in a mouse pre- and post-natal study. These data demonstrate a favorable pre-clinical reproductive safety profile for emtricitabine[2].
Cell Assay EA.hy926 cells were plated in a 12-, 24- or 96-well plates and grown in DMEM media supplemented with 3% FCS. Endothelial cells from PARP+/+and PARP-/- mice were isolated and cultured. Cell viability was determined by the reduction of yellow MTT into a purple formazan product by mitochondrial dehydrogenases of metabolically active cells. Following the treatment period, the experimental medium was removed and 100 μL MTT (1 mg/mL) added. After 1 h incubation, the MTT solution was carefully removed and the purple crystals were solubilized in 100 μL of DMSO. The DMSO was transferred to an ELISA plate and absorbance measured at 550 nm with a 620 nm[3].
Animal Admin Mice: Emtricitabine (free base) is suspended in 0.5% aqueous methylcellulose and given by gavage, with the daily dose divided into two equal installments administered approximately 6 h apart. The dose volume is 5 mL/kg/dose (10 mL/kg/day). In 1- and 6-month oral toxicity studies in mice, the maximum tolerated dose of emtricitabine is >3000 mg/kg/day. However, dose-range-finding studies are performed in pregnant CD-1 mice and in New Zealand White rabbits at top doses of 1000 mg/kg/day[2]. Rabbits: Mature artificially inseminated rabbits are given emtricitabine on gestational day 7 through 19. On gestational day 19, blood samples for toxicokinetics are taken from five satellite does in each group at 30–60 min prior to dosing, and at 1, 3, 7, and 12 h after the first daily-dose (prior to the second daily-dose). On gestational day 20, the satellite does are sacrificed at 1 h after the final dose, and maternal blood and fetal umbilical blood samples are collected for toxicokinetics[2].
References

[1]. Saag MS, et al. Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus. Clin Infect Dis.?2006 Jan 1;42(1):126-31.?

[2]. Szczech GM, Wang LH, Walsh JP, Reproductive toxicology profile of emtricitabine in mice and rabbits. Reprod Toxicol. 2003 Jan-Feb;17(1):95-108.

[3]. Faltz M, et al. Effect of the Anti-retroviral Drugs Efavirenz, Tenofovir and Emtricitabine on Endothelial Cell Function: Role of PARP. Cardiovasc Toxicol. 2017 Jan 3. [Epub ahead of print]

[4]. Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 443.3±55.0 °C at 760 mmHg
Melting Point 136-140°C
Molecular Formula C8H10FN3O3S
Molecular Weight 247.247
Flash Point 221.9±31.5 °C
Exact Mass 247.042694
PSA 115.67000
LogP -0.41
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.731
Storage condition -20°C Freezer

 Safety Information

Hazard Codes Xi
Safety Phrases S26-S36
RIDADR 2446
WGK Germany 3
Packaging Group III
Hazard Class 6.1
HS Code 2934999090

 Synthetic Route

2',3'-dideoxy-5-fluoro-3'-thiacytidine hydrochloride structure

2',3'-dideoxy-5...

CAS#:258832-61-0

~79%

Emtricitabine Structure

Emtricitabine

CAS#:143491-57-0

Literature: MATRIX LABORATORIES LIMITED Patent: WO2009/84033 A2, 2009 ; Location in patent: Page/Page column 10 ;
(2R,5S)-5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-Oxathiolane-2-carboxylic acid, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester structure

(2R,5S)-5-(4-am...

CAS#:764659-72-5

~63%

Emtricitabine Structure

Emtricitabine

CAS#:143491-57-0

Literature: Esteve Química, S.A. Patent: EP2377862 A1, 2011 ; Location in patent: Page/Page column 7 ;
N/A structure

N/A

CAS#:1313482-37-9

~%

Emtricitabine Structure

Emtricitabine

CAS#:143491-57-0

Literature: WO2011/83484 A2, ; Page/Page column 17 ;
N/A structure

N/A

CAS#:1321928-76-0

~%

Emtricitabine Structure

Emtricitabine

CAS#:143491-57-0

Literature: WO2011/95987 A1, ; Page/Page column 39 ;
(-)-(2R,5S)-5-fluoro-1-[2-[[(tert-butyldiphenylsilyl)oxy]methyl]-1,3-oxathiolan-5-yl]-N4-benzoylcytosine structure

(-)-(2R,5S)-5-f...

CAS#:145913-69-5

~%

Emtricitabine Structure

Emtricitabine

CAS#:143491-57-0

Literature: Journal of Medicinal Chemistry, , vol. 36, # 2 p. 181 - 195
5-(4-acetylamino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid 2-isopropyl-5-methyl-cyclohexyl ester structure

5-(4-acetylamin...

CAS#:1321928-75-9

~%

Emtricitabine Structure

Emtricitabine

CAS#:143491-57-0

Literature: WO2011/95987 A1, ;

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Emtricitabine
EMTRICITABIN
Emtriva
2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
4-Amino-5-fluor-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-on
EMTRITABINE
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxyméthyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
Coviracil
4-Amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
FTC
(-)-β-L-FTC
Entricitabine
(-)-FTC
4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
SM-Q
MFCD00870151
4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
2'-deoxy-5-fluoro-3'-thiacytidine
UNII-ULS8902U4O
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