Diprenorphine
Modify Date: 2025-09-03 23:33:04
Diprenorphine structure
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Common Name | Diprenorphine | ||
|---|---|---|---|---|
| CAS Number | 14357-78-9 | Molecular Weight | 425.56000 | |
| Density | 1.33 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H35NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DiprenorphineDiprenorphine is a non-selective opioid antagonist with Ki values of 0.017, 0.072 and 0.23 nM against κ-, μ- and δ-opioid receptors, respectively[1]. Diprenorphine can be used for central poststroke pain (CPSP) research[1]. |
| Name | Diprenorphine,17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol |
|---|---|
| Synonym | More Synonyms |
| Description | Diprenorphine is a non-selective opioid antagonist with Ki values of 0.017, 0.072 and 0.23 nM against κ-, μ- and δ-opioid receptors, respectively[1]. Diprenorphine can be used for central poststroke pain (CPSP) research[1]. |
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| Related Catalog | |
| Target |
Ki: 0.017 nM (κ-opioid receptor), 0.072 nM (μ-opioid receptor), 0.23 nM (δ-opioid receptor)[1] |
| References |
| Density | 1.33 g/cm3 |
|---|---|
| Molecular Formula | C26H35NO4 |
| Molecular Weight | 425.56000 |
| Exact Mass | 425.25700 |
| PSA | 62.16000 |
| LogP | 3.32550 |
| Index of Refraction | 1.656 |
| InChIKey | OIJXLIIMXHRJJH-KNLIIKEYSA-N |
| SMILES | COC12CCC3(CC1C(C)(C)O)C1Cc4ccc(O)c5c4C3(CCN1CC1CC1)C2O5 |
| Hazard Codes | Xn: Harmful; |
|---|---|
| Risk Phrases | R20/21/22 |
CAS#:1489-69-6
CAS#:2579-67-1
CAS#:16528-12-4
CAS#:74-88-4
CAS#:72221-15-9|
Name: Compound was evaluated for equilibrium constant, Ke
Source: ChEMBL
Target: N/A
External Id: CHEMBL631528
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Name: Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain memb...
Source: ChEMBL
Target: Mu-type opioid receptor
External Id: CHEMBL755008
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Name: Inhibition of 0.5 nM [3H]- Bremazocine binding to Opioid receptor mu 1 of bovine stri...
Source: ChEMBL
Target: Mu-type opioid receptor
External Id: CHEMBL753769
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Name: Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes ...
Source: ChEMBL
Target: Kappa-type opioid receptor
External Id: CHEMBL4372802
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Name: [3H]Diprenorphine Competition Assay from Article 10.1074/jbc.M113.515668: "Chemotype-...
Source: BindingDB
Target: N/A
External Id: BindingDB_7766_1
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Name: Binding affinity using [3H]diprenorphine as the radioligand against E297A mutant Opio...
Source: ChEMBL
Target: Kappa-type opioid receptor
External Id: CHEMBL747232
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Name: Human kappa receptor (Opioid receptors)
Source: IUPHAR-DB
Target: kappa receptor (Opioid receptors) [Homo sapiens]
External Id: 318_Human
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Name: Mouse mu receptor (Opioid receptors)
Source: IUPHAR-DB
Target: mu receptor (Opioid receptors) [Mus musculus]
External Id: 319_Mouse
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Name: Partition coefficient (logP) calculated between octanol-water for the free base relat...
Source: ChEMBL
Target: N/A
External Id: CHEMBL631690
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Name: Binding affinity using [3H]diprenorphine as the radioligand against K303E Opioid rece...
Source: ChEMBL
Target: Mu-type opioid receptor
External Id: CHEMBL873929
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| DIPRENORPHINE |
| RX-5050M |
| Diprenorphin |
| DIPRENORPHINE POTENT OPIOID ANTAGON |
| diprenorpine |
| M-5050 |