TWIK-1/TREK-1-IN-3

Modify Date: 2025-08-24 10:36:20

TWIK-1/TREK-1-IN-3 Structure
TWIK-1/TREK-1-IN-3 structure
 Common Name TWIK-1/TREK-1-IN-3
CAS Number 1440532-33-1 Molecular Weight 372.43
Density N/A Boiling Point N/A
Molecular Formula C19H27F3N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TWIK-1/TREK-1-IN-3


TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects[1].

 Names

Name TWIK-1/TREK-1-IN-3

 TWIK-1/TREK-1-IN-3 Biological Activity

Description TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects[1].
Related Catalog
Target

IC50: 9.74 μM (TREK-1/TREK-1), 16.5 μM (TWIK-1/TREK-1)[1]

References

[1]. Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.. .  

 Chemical & Physical Properties

Molecular Formula C19H27F3N2O2
Molecular Weight 372.43
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Chemsrc provides TWIK-1/TREK-1-IN-3(CAS#:1440532-33-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of TWIK-1/TREK-1-IN-3 are included as well.>> amp version: TWIK-1/TREK-1-IN-3

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