ROMK-IN-25

Modify Date: 2024-02-06 19:53:08

ROMK-IN-25 Structure
ROMK-IN-25 structure
Common Name ROMK-IN-25
CAS Number 1443735-02-1 Molecular Weight 462.489
Density N/A Boiling Point N/A
Molecular Formula C23H23FN8O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ROMK-IN-25


ROMK-IN-25 is a potent and selective ROMK channel (KCNJ1) inhibitor with IC50 of 72 nM; displays improved ROMK/hERG selectivity (866-fold over hERG), and improved pharmacokinetic profiles; does not evoke QTc prolongation in an in vivo cardiovascular dog model.

 Names

Name ROMK-IN-25

 ROMK-IN-25 Biological Activity

Description ROMK-IN-25 is a potent and selective ROMK channel (KCNJ1) inhibitor with IC50 of 72 nM; displays improved ROMK/hERG selectivity (866-fold over hERG), and improved pharmacokinetic profiles; does not evoke QTc prolongation in an in vivo cardiovascular dog model.
References References 1. Zhu Y, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5695-5702. View Related Products by Target Potassium Channel

 Chemical & Physical Properties

Molecular Formula C23H23FN8O2
Molecular Weight 462.489
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