Landiolol Hydrochloride

Modify Date: 2024-01-02 18:03:04

Landiolol Hydrochloride Structure
Landiolol Hydrochloride structure
Common Name Landiolol Hydrochloride
CAS Number 144481-98-1 Molecular Weight 546.053
Density 1.201g/cm3 Boiling Point 727.5ºC at 760mmHg
Molecular Formula C25H40ClN3O8 Melting Point 122-127ºC
MSDS N/A Flash Point 393.8ºC

 Use of Landiolol Hydrochloride


Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min), acts as an adrenoceptor antagonist[1].

 Names

Name Landiolol hydrochloride
Synonym More Synonyms

 Landiolol Hydrochloride Biological Activity

Description Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min), acts as an adrenoceptor antagonist[1].
Related Catalog
Target

beta-adrenergic receptor[1]

References

[1]. Atarashi H, et al. Pharmacokinetics of landiolol hydrochloride, a new ultra-short-acting beta-blocker, in patients with cardiac arrhythmias. Clin Pharmacol Ther. 2000 Aug;68(2):143-50.

[2]. Okajima M, et al. Landiolol, an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis. World J Crit Care Med. 2015 Aug 4;4(3):251-7.

 Chemical & Physical Properties

Density 1.201g/cm3
Boiling Point 727.5ºC at 760mmHg
Melting Point 122-127ºC
Molecular Formula C25H40ClN3O8
Molecular Weight 546.053
Flash Point 393.8ºC
Exact Mass 545.250366
PSA 127.82000
LogP 2.37760
Vapour Pressure 3.24E-22mmHg at 25°C

 Safety Information

RTECS DA8346700

 Synthetic Route

~48%

Landiolol Hydrochloride Structure

Landiolol Hydro...

CAS#:144481-98-1

Literature: Procos S.p.A.; Garavaglia, Fabio; Roletto, Jacopo; Paissoni, Paolo Patent: EP2687521 A1, 2014 ; Location in patent: Paragraph 0053; 0054; 0055; 0056; 0057 ;

~77%

Landiolol Hydrochloride Structure

Landiolol Hydro...

CAS#:144481-98-1

Literature: Procos S.p.A.; Garavaglia, Fabio; Roletto, Jacopo; Paissoni, Paolo Patent: EP2687521 A1, 2014 ; Location in patent: Paragraph 0051; 0052 ;

~%

Landiolol Hydrochloride Structure

Landiolol Hydro...

CAS#:144481-98-1

Literature: EP2687521 A1, ;

 Synonyms

((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-(2-(morpholine-4-carboxamido)ethylamino)propoxy)phenyl)propanoate hydrochloride
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate hydrochloride
(-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-3-[4-[(S)-2-hydroxy-3-(2-morpholinocarbonylamino)ethylamino]propoxy]phenylpropionic acid hydrochloride
(-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(S)-2-hydroxy-3-(2-(morpholinocarbonylamino)ethylamino)propoxy]phenyl]propionate monohydrochloride
Benzenepropanoic acid,4-(2-hydroxy-3-((2-((4-morpholinylcarbonyl)amino)ethyl)amino)propoxy)-,(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester,(S-(R*,R*))-,hydrochloride
Landiololhydrochloride
Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester, hydrochloride (1:1)
Ono 1101 hydrochloride
2,2-dimethyl-1,3-dioxolan-4S-yl-methyl 3-[P-{3-{(2-(morpholinocarbonylamino)ethyl)amino}-2S-hydroxypropoxy}phenyl] propionate hydrochloride
[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-{4-[(2S)-2-hydroxy-3-({2-[(4-morpholinylcarbonyl)amino]ethyl}amino)propoxy]phenyl}propanoate hydrochloride (1:1)
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Price: ¥500/5 mg

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