MI-2-2
Modify Date: 2024-01-02 17:04:38
MI-2-2 structure
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Common Name | MI-2-2 | ||
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| CAS Number | 1454920-20-7 | Molecular Weight | 415.499 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 515.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H20F3N5S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 265.3±32.9 °C | |
Use of MI-2-2MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation[1]. |
| Name | 4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine |
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| Synonym | More Synonyms |
| Description | MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation[1]. |
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| Related Catalog | |
| In Vitro | MI-2-2 is capable of inhibiting both the interaction of menin with MBM1 (IC50= 46 nM) and with the bivalent fragment of MLL that comprises both MBM1 and MBM2 (IC50=520 nM). MI-2-2 exhibits very pronounced activities at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4;11, a human leukemia cell line harboring the MLL-AF4 translocation[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 515.1±60.0 °C at 760 mmHg |
| Molecular Formula | C17H20F3N5S2 |
| Molecular Weight | 415.499 |
| Flash Point | 265.3±32.9 °C |
| Exact Mass | 415.111206 |
| LogP | 2.22 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.680 |
| Storage condition | 2-8°C |
| Thieno[2,3-d]pyrimidine, 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)- |
| 4-[4-(5,5-Dimethyl-4,5-Dihydro-1,3-Thiazol-2-Yl)piperazin-1-Yl]-6-(2,2,2-Trifluoroethyl)thieno[2,3-D]pyrimidine |
| 4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine |
| MFCD29044864 |