(D-Ser(tBu)6,AzaGly10)-LHRH acetate salt
(D-Ser(tBu)6,AzaGly10)-LHRH acetate salt structure
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Common Name | (D-Ser(tBu)6,AzaGly10)-LHRH acetate salt | ||
|---|---|---|---|---|
| CAS Number | 145781-92-6 | Molecular Weight | 1329.46 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 1695.5ºC at 760mmHg | |
| Molecular Formula | C61H88N18O16 | Melting Point | >190°C (dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS08 |
Signal Word | Danger | |
Use of (D-Ser(tBu)6,AzaGly10)-LHRH acetate saltGoserelin (ICI 118630) acetate is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).IC50 value:Target: GnRH agonistGoserelin is used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty. It may also be used in the treatment of male-to-female transsexuals and is favoured above other anti-androgens in some countries, such as the UK. It is available as a 1-month depot and a long-acting 3-month depot. Goserelin stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Goserelin Acetate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Goserelin (ICI 118630) acetate is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).IC50 value:Target: GnRH agonistGoserelin is used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty. It may also be used in the treatment of male-to-female transsexuals and is favoured above other anti-androgens in some countries, such as the UK. It is available as a 1-month depot and a long-acting 3-month depot. Goserelin stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. |
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| Related Catalog |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 1695.5ºC at 760mmHg |
| Melting Point | >190°C (dec.) |
| Molecular Formula | C61H88N18O16 |
| Molecular Weight | 1329.46 |
| PSA | 493.39000 |
| LogP | -0.95 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.692 |
| InChIKey | IKDXDQDKCZPQSZ-JHYYTBFNSA-N |
| SMILES | CC(=O)O.CC(C)CC(NC(=O)C(COC(C)(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(N)=O |
| Storage condition | −20°C |
| Water Solubility | H2O: 20 mg/mL, clear, colorless |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P280-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | OK6369800 |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Stability of peptide drugs in the colon.
Eur. J. Pharm. Sci. 78 , 31-6, (2015) This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclo... |
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Targeted gold nanoparticles enhance sensitization of prostate tumors to megavoltage radiation therapy in vivo.
Nanomedicine: Nanotechnology, Biology, and Medicine 11 , 1277-83, (2015) We report potent radiosensitization of prostate cancers in vitro and in vivo using goserelin-conjugated gold nanorods. Progressive receptor-mediated internalization of conjugated nanorods over time in... |
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Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs.
Mol. Pharm. 12(3) , 966-73, (2015) A major barrier to successful oral delivery of peptide and protein molecules is their inherent instability in the lumen of the gastrointestinal tract. The aim of this study was to determine the stabil... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Goserelin acetate |
| Goserelin acetate [D-Ser(tBu)6,Azagly10]-LHRH acetate salt |
| Goserelin (acetate) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of Goserelin Acetate? |
| A: CAS number of Goserelin Acetate is 145781-92-6. |
| Q: What is the molecular weight of Goserelin Acetate? |
| A: Molecular weight of Goserelin Acetate is 1329.46. |
| Q: What is the InChIKey of Goserelin Acetate? |
| A: InChIKey of Goserelin Acetate is IKDXDQDKCZPQSZ-JHYYTBFNSA-N. |
| Q: What is the SMILES notation of Goserelin Acetate? |
| A: SMILES notation of Goserelin Acetate is CC(=O)O.CC(C)CC(NC(=O)C(COC(C)(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(N)=O. |
| Q: What are the storage conditions for Goserelin Acetate? |
| A: Storage conditions for Goserelin Acetate: −20°C. |
| Q: How is the water solubility of Goserelin Acetate? |
| A: Water solubility of Goserelin Acetate: H2O: 20 mg/mL, clear, colorless. |
| Q: What is the LogP of Goserelin Acetate? |
| A: LogP of Goserelin Acetate is -0.95. |
| Q: What is the safety information for Goserelin Acetate? |
| A: Safety information for Goserelin Acetate: 22-24/25. |
| Q: What is the boiling point of Goserelin Acetate? |
| A: Boiling point of Goserelin Acetate is 1695.5ºC at 760mmHg. |
| Q: What is the English name of Goserelin Acetate? |
| A: The English name of Goserelin Acetate is Goserelin Acetate. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |