FR901464

Modify Date: 2024-01-11 17:35:04

FR901464 structure	Common Name	FR901464
	CAS Number	146478-72-0	Molecular Weight	507.61600
	Density	1.21g/cm3	Boiling Point	702.7ºC at 760mmHg
	Molecular Formula	C₂₇H₄₁NO₈	Melting Point	N/A
	MSDS	N/A	Flash Point	378.8ºC

Use of FR901464

FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].

Name	fr901464
Synonym	More Synonyms

Description	FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	FR901464 (10-20 ng/ml; 6-24 hours) inhibits the growth of murine solid tumors, Colon 38 carcinoma and Meth A fibrosarcoma. FR901464 induces characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA with the same kinetics as activation of SV40 promoter-dependent cellular transcription in M-8 tumor cells[1]. FR901464 (1-10 ng/ml; 16 hours) suppresses the transcription of some inducible endogenous genes but not house keeping genes in M-8 cells[1]. FR901464 exhibits potent anticancer activity. It shows enhancement of activity of a promoter of the SV40 DNA tumor virus at 10 nM concentration in M-8 cells[1].
References	[1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11. [2]. Arun K Ghosh, et al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79(12):5697-709.

Density	1.21g/cm3
Boiling Point	702.7ºC at 760mmHg
Molecular Formula	C₂₇H₄₁NO₈
Molecular Weight	507.61600
Flash Point	378.8ºC
Exact Mass	507.28300
PSA	130.34000
LogP	3.15270
Vapour Pressure	7.94E-23mmHg at 25°C
Index of Refraction	1.553

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZC0702750

CHEMICAL NAME :: WB 2663B

CAS REGISTRY NUMBER :: 146478-72-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 49,1196,1996

Hazard Codes	Xi

Precursor 5
CAS#:391611-36-2 Spliceostatin A CAS#:882028-32-2 (3R,4R,5R,7S)-7... CAS#:882028-36-6 (S)-4-formylbut... CAS#:882028-38-8 tert-butyl ((3R...
CAS#:882028-35-5 (E)-(2S)-6-phen...
DownStream 0

WB 2663B

[(E,2S)-5-[[(2R,5S,6S)-6-[(2E,4E)-5-[(4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate

[(E,2S)-5-[[(2R,5S,6S)-6-[(2E,4E)-5-[(5S,7R,8R)-5,8-dihydroxy-5-methyl-2,6-dioxaspiro[2.5]octan-7-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: FR-901464
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: FR-901464
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: FR-901464
Price: $950.0/10mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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FR901464

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