FR901464

Modify Date: 2024-01-11 17:35:04

FR901464 Structure
FR901464 structure
Common Name FR901464
CAS Number 146478-72-0 Molecular Weight 507.61600
Density 1.21g/cm3 Boiling Point 702.7ºC at 760mmHg
Molecular Formula C27H41NO8 Melting Point N/A
MSDS N/A Flash Point 378.8ºC

 Use of FR901464


FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].

 Names

Name fr901464
Synonym More Synonyms

 FR901464 Biological Activity

Description FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].
Related Catalog
In Vitro FR901464 (10-20 ng/ml; 6-24 hours) inhibits the growth of murine solid tumors, Colon 38 carcinoma and Meth A fibrosarcoma. FR901464 induces characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA with the same kinetics as activation of SV40 promoter-dependent cellular transcription in M-8 tumor cells[1]. FR901464 (1-10 ng/ml; 16 hours) suppresses the transcription of some inducible endogenous genes but not house keeping genes in M-8 cells[1]. FR901464 exhibits potent anticancer activity. It shows enhancement of activity of a promoter of the SV40 DNA tumor virus at 10 nM concentration in M-8 cells[1].
References

[1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11.

[2]. Arun K Ghosh, et al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79(12):5697-709.

 Chemical & Physical Properties

Density 1.21g/cm3
Boiling Point 702.7ºC at 760mmHg
Molecular Formula C27H41NO8
Molecular Weight 507.61600
Flash Point 378.8ºC
Exact Mass 507.28300
PSA 130.34000
LogP 3.15270
Vapour Pressure 7.94E-23mmHg at 25°C
Index of Refraction 1.553

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZC0702750
CHEMICAL NAME :
WB 2663B
CAS REGISTRY NUMBER :
146478-72-0
LAST UPDATED :
199806
DATA ITEMS CITED :
1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 49,1196,1996

 Safety Information

Hazard Codes Xi

 Synthetic Route

 Synonyms

WB 2663B
[(E,2S)-5-[[(2R,5S,6S)-6-[(2E,4E)-5-[(4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate
[(E,2S)-5-[[(2R,5S,6S)-6-[(2E,4E)-5-[(5S,7R,8R)-5,8-dihydroxy-5-methyl-2,6-dioxaspiro[2.5]octan-7-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: FR-901464
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

Get all suppliers and price by the below link:

FR901464 suppliers

FR901464 price

Hot Compounds More...
Dichloromethane
CAS#:75-09-2
Polyacrylic acid
CAS#:9003-01-4
sodium carbonate
CAS#:497-19-8
Silicon dioxide
CAS#:7631-86-9
Triethanolamine
CAS#:102-71-6
Demeton
CAS#:126-75-0
Water
CAS#:7732-18-5
4-(4-Piperidinyl)morpholine dihydrochloride
CAS#:53617-35-9
Diclofenac sodium
CAS#:15307-79-6
Budesonide
CAS#:51372-29-3