FR901464

• 常用名: FR901464
• 英文名: FR901464
• CAS号: 146478-72-0
• 分子量: 507.61600
• 密度: 1.21g/cm3
• 沸点: 702.7ºC at 760mmHg
• 分子式: C₂₇H₄₁NO₈
• 熔点: N/A
• 闪点: 378.8ºC

FR901464用途

FR901464是一种有效的剪接体抑制剂,具有显著的抗肿瘤和抗癌作用[1]。

FR901464名称

• 英文名: fr901464

FR901464生物活性

• 描述: FR901464是一种有效的剪接体抑制剂,具有显著的抗肿瘤和抗癌作用[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: FR901464(10-20纳克/毫升；6-24小时)抑制小鼠实体瘤、结肠癌和Meth A纤维肉瘤的生长。FR901464诱导细胞周期的特征性G1期和G2/M期阻滞以及基因组DNA的核体间降解,其动力学与M-8肿瘤细胞中SV40启动子依赖性细胞转录的激活相同[1]。FR901464(1-10纳克/毫升；16小时)抑制M-8细胞中某些可诱导内源性基因的转录,但不抑制内务基因的转录[1]。FR901464具有强大的抗癌活性。它显示在M-8细胞中,在10nm浓度下SV40 DNA肿瘤病毒启动子的活性增强[1]。
• 参考文献:

  [1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11.

  [2]. Arun K Ghosh, et al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79(12):5697-709.

FR901464物理化学性质

• 密度: 1.21g/cm3
• 沸点: 702.7ºC at 760mmHg
• 分子式: C₂₇H₄₁NO₈
• 分子量: 507.61600
• 闪点: 378.8ºC
• 精确质量: 507.28300
• PSA: 130.34000
• LogP: 3.15270
• InChIKey: PJKVJJDQXZARCA-BKKUOFRBSA-N
• SMILES: CC(=O)OC(C)C=CC(=O)NC1CC(C)C(CC=C(C)C=CC2OC(C)(O)CC3(CO3)C2O)OC1C
• 蒸汽压: 7.94E-23mmHg at 25°C
• 折射率: 1.553
• 储存条件: -20°C，干燥，密封

FR901464毒性和生态

FR901464安全信息

• 危害码 (欧洲): Xi

FR901464靶点实验

查看更多实验

实验名称：Induction of p27 expression in human A549 cells at 1 to 100 ng/ml after 14 hrs by imm... 来源：ChEMBL 靶标：A549 External Id：CHEMBL1226354

实验名称：Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL2346159

实验名称：Induction of truncated p27 expression in HEK293T cells at 1 to 100 ng/ml after 14 hrs... 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL1226353

实验名称：Antiproliferative activity against human DU145 cells assessed as growth inhibition me... 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL2346158

实验名称：Induction of p27 expression in HEK293T cells at 1 to 100 ng/ml after 14 hrs by immuno... 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL1226352

实验名称：Antiproliferative activity against human NCI-H232A cells assessed as growth inhibitio... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2346157

实验名称：Induction of p21 expression in human HeLa cells at 100 ng/ml after 16 hrs by Western ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL1226351

实验名称：Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibiti... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL2346156

实验名称：Induction of p27 expression in human HeLa cells at 100 ng/ml after 16 hrs by Western ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL1226350

实验名称：Induction of p16 expression in human HeLa cells at 100 ng/ml after 16 hrs by Western ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL1226349

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FR901464英文别名

• WB 2663B
• [(E,2S)-5-[[(2R,5S,6S)-6-[(2E,4E)-5-[(4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate
• [(E,2S)-5-[[(2R,5S,6S)-6-[(2E,4E)-5-[(5S,7R,8R)-5,8-dihydroxy-5-methyl-2,6-dioxaspiro[2.5]octan-7-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate