(4-Oxo-4H-quinazolin-3-yl)-acetic acid
(4-Oxo-4H-quinazolin-3-yl)-acetic acid structure
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Common Name | (4-Oxo-4H-quinazolin-3-yl)-acetic acid | ||
|---|---|---|---|---|
| CAS Number | 14663-53-7 | Molecular Weight | 204.18200 | |
| Density | N/A | Boiling Point | 444.6ºC at 760mmHg | |
| Molecular Formula | C10H8N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (4-Oxo-4H-quinazolin-3-yl)-acetic acid(4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 2-(4-oxoquinazolin-3-yl)acetic acid |
|---|---|
| Synonym | More Synonyms |
| Description | (4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Boiling Point | 444.6ºC at 760mmHg |
|---|---|
| Molecular Formula | C10H8N2O3 |
| Molecular Weight | 204.18200 |
| Exact Mass | 204.05300 |
| PSA | 72.19000 |
| LogP | 0.48110 |
| Vapour Pressure | 1.1E-08mmHg at 25°C |
| Index of Refraction | 1.659 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2933990090 |
|
~89%
(4-Oxo-4H-quina... CAS#:14663-53-7 |
| Literature: Spulak, Marcel; Pourova, Jana; Voprsalova, Marie; Mikusek, Jiri; Kunes, Jiri; Vacek, Jan; Ghavre, Mukund; Gathergood, Nicholas; Pour, Milan European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 65 - 72 |
|
~90%
(4-Oxo-4H-quina... CAS#:14663-53-7 |
| Literature: Spulak, Marcel; Novak, Zdenek; Palat, Karel; Kunes, Jiri; Pourova, Jana; Pour, Milan Tetrahedron, 2013 , vol. 69, # 6 p. 1705 - 1711 |
|
~86%
(4-Oxo-4H-quina... CAS#:14663-53-7 |
| Literature: Escalante, Jaime; Flores, Patricia; Priego, Jaime M. Heterocycles, 2004 , vol. 63, # 9 p. 2019 - 2032 |
|
~87%
(4-Oxo-4H-quina... CAS#:14663-53-7 |
| Literature: Susse; Johne Helvetica Chimica Acta, 1985 , vol. 68, # 4 p. 892 - 899 |
|
~%
(4-Oxo-4H-quina... CAS#:14663-53-7 |
| Literature: Helvetica Chimica Acta, , vol. 68, # 4 p. 892 - 899 |
|
~%
(4-Oxo-4H-quina... CAS#:14663-53-7 |
| Literature: Heterocycles, , vol. 63, # 9 p. 2019 - 2032 |
|
~%
(4-Oxo-4H-quina... CAS#:14663-53-7 |
| Literature: Journal of Organic Chemistry, , vol. 17, p. 19,20 |
|
~%
(4-Oxo-4H-quina... CAS#:14663-53-7 |
| Literature: Helvetica Chimica Acta, , vol. 68, # 4 p. 892 - 899 |
|
~%
(4-Oxo-4H-quina... CAS#:14663-53-7 |
| Literature: Helvetica Chimica Acta, , vol. 68, # 4 p. 892 - 899 |
| Precursor 8 | |
|---|---|
| DownStream 1 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 4-Oxo-3,4-dihydro-chinazolyl-3-essigsaeure |
| 2-(4-oxo-3-hydroquinazolin-3-yl)acetic acid |
| (4-Oxo-4H-quinazolin-3-yl)-acetic acid |
| (4-oxo-3,4-dihydroquinazolin-3-yl)acetic acid |
| (4-Oxo-4H-chinazolin-3-yl)-essigsaeure |
| 3-carboxymethyl-3,4-dihydro-4(1H)-quinazolinone |
| (4-oxoquinazolin-3(4H)-yl)acetic acid |
| N-carboxymethyl-4(3H)-quinazolinone |
| 2-(4-oxo-3,4-dihydroquinazolin-3-yl)acetic acid |
| 2-(4-Oxoquinazolin-3(4H)-yl)acetic acid |
| 3(4h)-quinazolineacetic acid,4-oxo |
| (4-oxo-3,4-dihydroquinazolin-3-yl)acetate |