(4-氧代-3(4H)-喹唑啉基)乙酸

• 常用名: (4-氧代-3(4H)-喹唑啉基)乙酸
• 英文名: (4-Oxo-4H-quinazolin-3-yl)-acetic acid
• CAS号: 14663-53-7
• 分子量: 204.18200
• 密度: N/A
• 沸点: 444.6ºC at 760mmHg
• 分子式: C₁₀H₈N₂O₃
• 熔点: N/A
• 闪点: N/A

(4-氧代-3(4H)-喹唑啉基)乙酸用途

(4-Oxo-4H-quinazolin-3-yl)-acetic acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

(4-氧代-3(4H)-喹唑啉基)乙酸名称

• 中文名: (4-氧代-3(4H)-喹唑啉基)乙酸
• 英文名: 2-(4-oxoquinazolin-3-yl)acetic acid
• 中文别名: (4-氧代-4H-喹唑啉)-乙酸

(4-氧代-3(4H)-喹唑啉基)乙酸生物活性

• 描述: (4-Oxo-4H-quinazolin-3-yl)-acetic acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker
• 靶点实验:

  Alkyl-Chain

• 体外研究: PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。
• 参考文献:

  [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

(4-氧代-3(4H)-喹唑啉基)乙酸物理化学性质

• 沸点: 444.6ºC at 760mmHg
• 分子式: C₁₀H₈N₂O₃
• 分子量: 204.18200
• 精确质量: 204.05300
• PSA: 72.19000
• LogP: 0.48110
• InChIKey: BBBICQPTZBHLBM-UHFFFAOYSA-N
• SMILES: O=C(O)Cn1cnc2ccccc2c1=O
• 蒸汽压: 1.1E-08mmHg at 25°C
• 折射率: 1.659
• 储存条件: 2-8°C，干燥，密封

(4-氧代-3(4H)-喹唑啉基)乙酸安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

(4-氧代-3(4H)-喹唑啉基)乙酸海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(4-氧代-3(4H)-喹唑啉基)乙酸靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

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(4-氧代-3(4H)-喹唑啉基)乙酸英文别名

• 4-Oxo-3,4-dihydro-chinazolyl-3-essigsaeure
• 2-(4-oxo-3-hydroquinazolin-3-yl)acetic acid
• (4-Oxo-4H-quinazolin-3-yl)-acetic acid
• (4-oxo-3,4-dihydroquinazolin-3-yl)acetic acid
• (4-Oxo-4H-chinazolin-3-yl)-essigsaeure
• 3-carboxymethyl-3,4-dihydro-4(1H)-quinazolinone
• (4-oxoquinazolin-3(4H)-yl)acetic acid
• N-carboxymethyl-4(3H)-quinazolinone
• 2-(4-oxo-3,4-dihydroquinazolin-3-yl)acetic acid
• 2-(4-Oxoquinazolin-3(4H)-yl)acetic acid
• 3(4h)-quinazolineacetic acid,4-oxo
• (4-oxo-3,4-dihydroquinazolin-3-yl)acetate