NOC-5

Modify Date: 2024-01-05 18:23:16

NOC-5 Structure
NOC-5 structure
Common Name NOC-5
CAS Number 146724-82-5 Molecular Weight 176.217
Density 1.2±0.1 g/cm3 Boiling Point 270.1±42.0 °C at 760 mmHg
Molecular Formula C6H16N4O2 Melting Point N/A
MSDS USA Flash Point 117.2±27.9 °C

 Use of NOC-5


NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors[1].

 Names

Name 3-[2-Hydroxy-1-(1-Methylethyl)-2-Nitrosohydrazino]-1-Propanamine Discontinued
Synonym More Synonyms

 NOC-5 Biological Activity

Description NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors[1].
Related Catalog
In Vitro NOC-5 (5-20 μM) in PBS led to a rapid increase in NO release on day one[1]. NOC-5 (100 μM, 24 h) activates only caspase-3; an increase in caspase-3 activity occurred after NO donor treatment: 1.62 (1.57-1.66) (P < 0.05). NOC-5 has pro-apoptotic action in Jurkat cells, but at the same time increased the level of anti-apoptotic proteins[2].
References

[1]. Sophie A Bradley, et al. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. J Neurosci Methods. 2015 Apr 30;245:116-24.

[2]. Elena G Starikova, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38(7):799-802.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 270.1±42.0 °C at 760 mmHg
Molecular Formula C6H16N4O2
Molecular Weight 176.217
Flash Point 117.2±27.9 °C
Exact Mass 176.127319
PSA 90.60000
LogP 0.02
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.525

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26;S36
RIDADR NONH for all modes of transport

 Articles3

More Articles
The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts.

Food Funct. 6 , 3081-90, (2015)

Among the large number of scientifically unstudied fruits from the Amazonia biome, Couepia bracteosa acts as an interesting source of bioactive compounds, such as phenolic compounds and carotenoids, w...

Influence of coffee genotype on bioactive compounds and the in vitro capacity to scavenge reactive oxygen and nitrogen species.

J. Agric. Food Chem. 63 , 4815-26, (2015)

The influence of green coffee genotype on the bioactive compounds and the in vitro antioxidant capacity against the principal reactive oxygen (ROO(•), H2O2, HO(•), and HOCl) and nitrogen (NO(•) and ON...

Hrabie, J.A., et al.

J. Org. Chem. 58 , 1472, (1993)

 Synonyms

N-[3-aminopropyl(propan-2-yl)amino]-N-hydroxynitrous amide
3-(Aminopropyl)-1-hydroxy-3-isopropyl-2-oxo-1-triazene
1-(3-Aminopropyl)-2-hydroxy-1-isopropyl-3-oxotriazane
1-Propanamine, 3-[2-hydroxy-1-(1-methylethyl)-3-oxotriazanyl]-
3-(2-Hydroxy-1-(1-methylethyl)-2-nitrosohydrazino)-1-propanamine
MFCD00274389
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