Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NOC-5 - CAS 146724-82-5 - Calbiochem
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Purity: 98.0%
Stocking Period: 10 Day
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DC Chemicals Limited
China
Product Name: NOC-5
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

146724-82-5

146724-82-5 structure

146724-82-5 structure

Name: NOC-5
Chemical Name: 3-[2-Hydroxy-1-(1-Methylethyl)-2-Nitrosohydrazino]-1-Propanamine Discontinued
CAS Number: 146724-82-5
Molecular Formula: C₆H₁₆N₄O₂
Molecular Weight: 176.217
Catalog: Research Areas Cancer
Create Date: 2018-12-24 15:21:24
Modify Date: 2024-01-05 18:23:16
NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors[1].

Name	3-[2-Hydroxy-1-(1-Methylethyl)-2-Nitrosohydrazino]-1-Propanamine Discontinued
Synonyms	N-[3-aminopropyl(propan-2-yl)amino]-N-hydroxynitrous amide 3-(Aminopropyl)-1-hydroxy-3-isopropyl-2-oxo-1-triazene 1-(3-Aminopropyl)-2-hydroxy-1-isopropyl-3-oxotriazane 1-Propanamine, 3-[2-hydroxy-1-(1-methylethyl)-3-oxotriazanyl]- 3-(2-Hydroxy-1-(1-methylethyl)-2-nitrosohydrazino)-1-propanamine MFCD00274389

Description	NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	NOC-5 (5-20 μM) in PBS led to a rapid increase in NO release on day one[1]. NOC-5 (100 μM, 24 h) activates only caspase-3; an increase in caspase-3 activity occurred after NO donor treatment: 1.62 (1.57-1.66) (P < 0.05). NOC-5 has pro-apoptotic action in Jurkat cells, but at the same time increased the level of anti-apoptotic proteins[2].
References	[1]. Sophie A Bradley, et al. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. J Neurosci Methods. 2015 Apr 30;245:116-24. [2]. Elena G Starikova, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38(7):799-802.

Density	1.2±0.1 g/cm3
Boiling Point	270.1±42.0 °C at 760 mmHg
Molecular Formula	C₆H₁₆N₄O₂
Molecular Weight	176.217
Flash Point	117.2±27.9 °C
Exact Mass	176.127319
PSA	90.60000
LogP	0.02
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.525

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport

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