Cyclo(Phe-Pro)

Modify Date: 2025-08-25 11:37:25

Cyclo(Phe-Pro) Structure
Cyclo(Phe-Pro) structure
Common Name Cyclo(Phe-Pro)
CAS Number 14705-60-3 Molecular Weight 244.289
Density 1.3±0.1 g/cm3 Boiling Point 509.5±39.0 °C at 760 mmHg
Molecular Formula C14H16N2O2 Melting Point N/A
MSDS N/A Flash Point 262.0±27.1 °C

 Use of Cyclo(Phe-Pro)


Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses[1].

 Names

Name cyclo(phenylalanyl-prolyl)
Synonym More Synonyms

 Cyclo(Phe-Pro) Biological Activity

Description Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses[1].
Related Catalog
References

[1]. Lee W, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 509.5±39.0 °C at 760 mmHg
Molecular Formula C14H16N2O2
Molecular Weight 244.289
Flash Point 262.0±27.1 °C
Exact Mass 244.121185
LogP -0.56
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.614

 Synonyms

3-Benzyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione
3-Benzylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(phenylmethyl)-
cyclo(phenylalanyl-prolyl)
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