3705-26-8

3705-26-8 structure

Name: Cyclo(L-Phe-L-Pro)
Chemical Name: cyclo(-phe-pro)
CAS Number: 3705-26-8
Molecular Formula: C₁₄H₁₆N₂O₂
Molecular Weight: 244.289
Catalog: Natural product Alkaloid
Create Date: 2018-10-04 08:07:26
Modify Date: 2024-01-12 19:48:30
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation[2]. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay[3].

Name	cyclo(-phe-pro)
Synonyms	CYCLO-L-PHENYLALANYL-L-PROLINE (3S,8aS)-3-Benzylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (3S-trans)-3-Benzylhexahydropyrrolo(1,2-a)pyrazine-1,4-dione Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(phenylmethyl)-, (3S,8aS)- Einecs 223-047-0

Description	Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation[2]. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IFNAR Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology
References	[1]. Katrin Ström, et al. Lactobacillus plantarum MiLAB 393 Produces the Antifungal Cyclic Dipeptides Cyclo(L-Phe-L-Pro) and Cyclo(L-Phe-trans-4-OH-L-Pro) and 3-Phenyllactic Acid. Appl Environ Microbiol. 2002 Sep;68(9):4322-7. [2]. Wooseong Lee, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606. [3]. Keyong Ho Lee, et al. Radioprotective effect of cyclo(L-phenylalanyl-L-prolyl) on irradiated rat lung. J Microbiol Biotechnol. 2008 Feb;18(2):369-76.

Hazard Codes	Xi