3705-26-8

3705-26-8 structure

Name: Cyclo(L-Phe-L-Pro)
Chemical Name: cyclo(-phe-pro)
CAS Number: 3705-26-8
Molecular Formula: C₁₄H₁₆N₂O₂
Molecular Weight: 244.289
Catalog: Natural product Alkaloid
Create Date: 2018-10-04 08:07:26
Modify Date: 2026-08-06 19:09:46
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation[2]. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay[3].

Name	cyclo(-phe-pro)
Synonyms	Cyclo(L-phenylalanyl-L-prolyl) 4'-beta-D-glucopyranosyloxy-5,7-dihydroxyisoflavone CYCLO-L-PHENYLALANYL-L-PROLINE Einecs -0 (3S,8aS)-3-Benzylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (3S,8aα)-3β-Benzyloctahydropyrrolo[1,2-a]pyrazine-1,4-dione Cyclo(D-Pro-L-Phe-) Cyclo(-Phe-Pro) (TLC) Maculosine 2 (3S)-2,3,6,7,8,8aβ-Hexahydro-3β-(phenylmethyl)pyrrolo[1,2-a]pyrazine-1,4-dione Cyclo(L Phe L Pro),Cyclo(LPheLPro) Einecs 223-047-0 (3S,8aS)-3-Benzyl-6,7,8,8aα-tetrahydropyrrolo[1,2-a]pyrazine-1,4(2H,3H)-dione L-Phenylalanyl-L-proline lactam Cyclo(Pro-Phe-) L-Prolyl-L-phenylalanine diketopiperazine (3S-trans)-3-Benzylhexahydropyrrolo(1,2-a)pyrazine-1,4-dione (3S,8aS)-3β-Benzyl-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazine-1,4(2H,3H)-dione Cyclo(L-prolyl-L-phenylalanyl) c(Phe-Pro) (3S,8AS)-3-benzylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(phenylmethyl)-, (3S,8aS) Cyclo(L-Phe-L-Pro-) (3S-trans)-3-benzylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Description	Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation[2]. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IFNAR Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology
References	[1]. Katrin Ström, et al. Lactobacillus plantarum MiLAB 393 Produces the Antifungal Cyclic Dipeptides Cyclo(L-Phe-L-Pro) and Cyclo(L-Phe-trans-4-OH-L-Pro) and 3-Phenyllactic Acid. Appl Environ Microbiol. 2002 Sep;68(9):4322-7. [2]. Wooseong Lee, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606. [3]. Keyong Ho Lee, et al. Radioprotective effect of cyclo(L-phenylalanyl-L-prolyl) on irradiated rat lung. J Microbiol Biotechnol. 2008 Feb;18(2):369-76.

Hazard Codes	Xi