7ACC2

Modify Date: 2025-08-25 08:06:16

7ACC2 Structure
7ACC2 structure
Common Name 7ACC2
CAS Number 1472624-85-3 Molecular Weight 309.316
Density 1.4±0.1 g/cm3 Boiling Point 548.9±50.0 °C at 760 mmHg
Molecular Formula C18H15NO4 Melting Point N/A
MSDS N/A Flash Point 285.8±30.1 °C

 Use of 7ACC2


7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.

 Names

Name 7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid
Synonym More Synonyms

 7ACC2 Biological Activity

Description 7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.
Related Catalog
References

[1]. Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 548.9±50.0 °C at 760 mmHg
Molecular Formula C18H15NO4
Molecular Weight 309.316
Flash Point 285.8±30.1 °C
Exact Mass 309.100098
LogP 4.17
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.672
Storage condition 2-8℃

 Synonyms

2H-1-Benzopyran-3-carboxylic acid, 7-[methyl(phenylmethyl)amino]-2-oxo-
7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid
7ACC2
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