7ACC2

• 常用名: 7ACC2
• 英文名: 7ACC2
• CAS号: 1472624-85-3
• 分子量: 309.316
• 密度: 1.4±0.1 g/cm3
• 沸点: 548.9±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₅NO₄
• 熔点: N/A
• 闪点: 285.8±30.1 °C

7ACC2用途

7ACC2是MCT高效抑制剂，对[14C]-乳酸流入抑制的IC50值为11nM，是针对癌细胞乳酸转运的新型抗肿瘤分子。

7ACC2名称

• 中文名: 7ACC2
• 英文名: 7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid

7ACC2生物活性

• 描述: 7ACC2是MCT高效抑制剂,对[14C]-乳酸流入抑制的IC50值为11nM,是针对癌细胞乳酸转运的新型抗肿瘤分子。
• 相关类别:
  信号通路 >> 跨膜转运 >> 单羧酸转运蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17.

7ACC2物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 548.9±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₅NO₄
• 分子量: 309.316
• 闪点: 285.8±30.1 °C
• 精确质量: 309.100098
• LogP: 4.17
• InChIKey: XTKDQPFUOFAMRL-UHFFFAOYSA-N
• SMILES: CN(Cc1ccccc1)c1ccc2cc(C(=O)O)c(=O)oc2c1
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.672
• 储存条件: 2-8℃

7ACC2靶点实验

查看更多实验

实验名称：Toxicity in C57Bl6/J mouse assessed as induction of anticoagulant at 3 mg/kg, ip by p... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2444628

实验名称：Ratio of alpha-cyano-4-hydroxycinnamate IC50 to compound IC50 for MCT4-mediated [14C]... 来源：ChEMBL 靶标：Monocarboxylate transporter 4 External Id：CHEMBL2443718

实验名称：Tmax in mouse at 3 mg/kg, ip 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2444892

实验名称：Toxicity in C57Bl6/J mouse assessed as mortality at 3 mg/kg, ip 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2444891

实验名称：AUC (infinity) in mouse at 3 mg/kg, ip 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2444890

实验名称：Cytotoxicity against human SiHa cells in glucose-containing medium after 72 hrs by MT... 来源：ChEMBL 靶标：SiHa External Id：CHEMBL2444911

实验名称：Induction of apoptosis in human SiHa cells in lactate-containing medium assessed as c... 来源：ChEMBL 靶标：SiHa External Id：CHEMBL2444905

实验名称：Chemical stability of the compound in simulated gastric fluid assessed as compound re... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2444902

实验名称：Cytotoxicity against human SiHa cells in glucose-containing medium after 72 hrs by MT... 来源：ChEMBL 靶标：SiHa External Id：CHEMBL2444909

实验名称：Cytotoxicity against human SiHa cells in glucose-containing medium after 72 hrs by MT... 来源：ChEMBL 靶标：SiHa External Id：CHEMBL2444908

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7ACC2英文别名

• 7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid
• 7ACC2