Pregnenolone monosulfate-d4 sodium

Modify Date: 2024-01-16 12:12:28

Pregnenolone monosulfate-d4 sodium structure	Common Name	Pregnenolone monosulfate-d4 sodium
	CAS Number	1485492-21-4	Molecular Weight	422.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₇D₄NaO₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pregnenolone monosulfate-d4 sodium

Pregnenolone monosulfate-d4 (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

Name	Pregnenolone monosulfate-d4 sodium

Description	Pregnenolone monosulfate-d4 (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. [3]. Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34. [4]. Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14(1):7.

Molecular Formula	C₂₁H₂₇D₄NaO₅S
Molecular Weight	422.55

Pregnenolone monosulfate-d4 sodium

Use of Pregnenolone monosulfate-d4 sodium

Names

Pregnenolone monosulfate-d4 sodium Biological Activity

Chemical & Physical Properties