Pregnenolone monosulfate
Modify Date: 2024-01-21 11:53:22
Pregnenolone monosulfate structure
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Common Name | Pregnenolone monosulfate | ||
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| CAS Number | 1247-64-9 | Molecular Weight | 396.54100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H32O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Pregnenolone monosulfatePregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC). |
| Name | pregnenolone sulfate |
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| Description | Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC). |
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| Related Catalog | |
| Target |
CB1 Receptor Human Endogenous Metabolite |
| In Vitro | The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC)[1]. |
| In Vivo | Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1]. |
| Animal Admin | Mice and Rats[1] Adult male Wistar rats (weighing 320-340g), Sprague Dawley male rats (weighing 330-350g), C57BL/6N mice (2-3 months) and CD1 mice (weighing 25-30 g at the beginning of the experiments) are used. Pregnenolone is injected subcutaneously (sc). The injection volumes are 1 mL/kg of body weight for rats and 10 mL/kg for mice[1]. |
| References |
| Molecular Formula | C21H32O5S |
|---|---|
| Molecular Weight | 396.54100 |
| Exact Mass | 396.19700 |
| PSA | 89.05000 |
| LogP | 5.42320 |
| Storage condition | -20°C |