Fmoc-Lys(Pal-Glu-OtBu)-OH
Modify Date: 2024-01-04 12:15:14
Fmoc-Lys(Pal-Glu-OtBu)-OH structure
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Common Name | Fmoc-Lys(Pal-Glu-OtBu)-OH | ||
|---|---|---|---|---|
| CAS Number | 1491158-62-3 | Molecular Weight | 792.055 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 944.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C46H69N3O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 524.8±34.3 °C | |
Use of Fmoc-Lys(Pal-Glu-OtBu)-OHFmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
| Name | (2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-6-{[(4S)-5-[(2-methyl-2-propanyl)oxy]-5-oxo-4-(palmitoylamino)pentanoyl]amino}hexanoic acid (non-preferred name) |
|---|---|
| Synonym | More Synonyms |
| Description | Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 944.2±65.0 °C at 760 mmHg |
| Molecular Formula | C46H69N3O8 |
| Molecular Weight | 792.055 |
| Flash Point | 524.8±34.3 °C |
| Exact Mass | 791.508484 |
| LogP | 11.05 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.530 |
| Hazard Codes | Xi |
|---|
| MFCD27952849 |
| N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-[N-(1-oxohexadecyl)-L-gamma-glutamyl]-L-lysine 1'-(1,1-dimethylethyl) ester |
| Fmoc-Lys(Pal-Glu-Otbu)-OH |
- Chengdu Pukang Biotechnology Co., Ltd.
- China
- Product Name: Fmoc-Lys(Pal-Glu-OtBu)-OH
- Price: ￥Inquiry/10g
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Lihua Yang
- DC Chemicals Limited
- China
- Product Name: Fmoc-Lys(Pal-Glu-OtBu)-OH
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Nanjing Peptide Biotech Ltd
- China
- Product Name: Fmoc-Lys(Pal-Glu-OtBu)-OH
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
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