Cidofovir Dihydrate

Modify Date: 2024-01-04 16:01:15

Cidofovir Dihydrate structure	Common Name	Cidofovir Dihydrate
	CAS Number	149394-66-1	Molecular Weight	315.22
	Density	1.8±0.1 g/cm3	Boiling Point	609.5±65.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₈N₃O₈P	Melting Point	260ºC (dec)
	MSDS	N/A	Flash Point	322.4±34.3 °C

Use of Cidofovir Dihydrate

Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis.Target: CMV DNA polymeraseCidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is an acyclic nucleoside phosphonate, and is therefore independent of phosphorylation by viral enzymes, unlike acyclovir.Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, by Antonín Hol?, and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere. Maintenance therapy with cidofovir involves an infusion only once every two weeks, making it a convenient treatment option. Because dosing is relatively infrequent, a permanent catheter is not necessary for infusions.

Name	cidofovir dihydrate
Synonym	More Synonyms

Description	Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis.Target: CMV DNA polymeraseCidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is an acyclic nucleoside phosphonate, and is therefore independent of phosphorylation by viral enzymes, unlike acyclovir.Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, by Antonín Hol?, and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere. Maintenance therapy with cidofovir involves an infusion only once every two weeks, making it a convenient treatment option. Because dosing is relatively infrequent, a permanent catheter is not necessary for infusions.
Related Catalog	Signaling Pathways >> Anti-infection >> CMV Research Areas >> Infection
References	[1]. Becker MN, et al. Isolation and characterization of cidofovir resistant vaccinia viruses. Virol J. 2008 May 14;5:58. [2]. Kazory A, et al. Simultaneous development of Fanconi syndrome and acute renal failure associated with cidofovir. J Antimicrob Chemother. 2007 Jul;60(1):193-4. Epub 2007 May 11. [3]. Segarra-Newnham M, et al. Use of cidofovir in progressive multifocal leukoencephalopathy. Ann Pharmacother. 2001 Jun;35(6):741-4.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> CMV

Research Areas >> Infection

References

[1]. Becker MN, et al. Isolation and characterization of cidofovir resistant vaccinia viruses. Virol J. 2008 May 14;5:58.

[2]. Kazory A, et al. Simultaneous development of Fanconi syndrome and acute renal failure associated with cidofovir. J Antimicrob Chemother. 2007 Jul;60(1):193-4. Epub 2007 May 11.

[3]. Segarra-Newnham M, et al. Use of cidofovir in progressive multifocal leukoencephalopathy. Ann Pharmacother. 2001 Jun;35(6):741-4.

Density	1.8±0.1 g/cm3
Boiling Point	609.5±65.0 °C at 760 mmHg
Melting Point	260ºC (dec)
Molecular Formula	C₈H₁₈N₃O₈P
Molecular Weight	315.22
Flash Point	322.4±34.3 °C
PSA	157.71000
LogP	-3.37
Vapour Pressure	0.0±4.0 mmHg at 25°C
Index of Refraction	1.656

Cidofovir hydrate (1:2)

Gs-0504

Phosphonic acid, [[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-

Cidofovir dihydrate

({[(2S)-1-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid

Cidofovir

(S)-[[2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic Acid

Unii-jil713Q00n

(S)-HPMPC Hydrate

Cidovir Hydrate

Vistide Hydrate

(S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl-1-(hydroxymethyl)ethoxy)methyl phosphonic acid

({[(2S)-1-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-3-hydroxy-2-propanyl]oxy}methyl)phosphonic acid

Vistide

Drg-0145

Cidofovir hydrate

GS 0504 Hydrate

Cidofovir (dihydrate)

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China
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China
Product Name: Cidofovir 2-hydrate
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Cidofovir Dihydrate

Use of Cidofovir Dihydrate

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Cidofovir Dihydrate Biological Activity

Chemical & Physical Properties

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