西多福韦

• 常用名: 西多福韦
• 英文名: Cidofovir Dihydrate
• CAS号: 149394-66-1
• 分子量: 315.22
• 密度: 1.8±0.1 g/cm3
• 沸点: 609.5±65.0 °C at 760 mmHg
• 分子式: C₈H₁₈N₃O₈P
• 熔点: 260ºC (dec)
• 闪点: 322.4±34.3 °C

西多福韦用途

Cidofovir是注射型巨细胞病毒（CMV）DNA聚合酶抑制剂。

西多福韦名称

• 中文名: 西多福韦二水合物
• 英文名: cidofovir dihydrate
• 中文别名: 西多福韦 | 西多福韦二水

西多福韦生物活性

• 描述: Cidofovir是注射型巨细胞病毒(CMV)DNA聚合酶抑制剂。
• 相关类别:
  信号通路 >> 抗感染 >> CMV
  研究领域 >> 感染
• 参考文献:

  [1]. Becker MN, et al. Isolation and characterization of cidofovir resistant vaccinia viruses. Virol J. 2008 May 14;5:58.

  [2]. Kazory A, et al. Simultaneous development of Fanconi syndrome and acute renal failure associated with cidofovir. J Antimicrob Chemother. 2007 Jul;60(1):193-4. Epub 2007 May 11.

  [3]. Segarra-Newnham M, et al. Use of cidofovir in progressive multifocal leukoencephalopathy. Ann Pharmacother. 2001 Jun;35(6):741-4.

西多福韦物理化学性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 609.5±65.0 °C at 760 mmHg
• 熔点: 260ºC (dec)
• 分子式: C₈H₁₈N₃O₈P
• 分子量: 315.22
• 闪点: 322.4±34.3 °C
• PSA: 157.71000
• LogP: -3.37
• InChIKey: FPKARFMSZDBYQF-ILKKLZGPSA-N
• SMILES: Nc1ccn(CC(CO)OCP(=O)(O)O)c(=O)n1.O.O
• 蒸汽压: 0.0±4.0 mmHg at 25°C
• 折射率: 1.656
• 储存条件: 室温，干燥

西多福韦靶点实验

查看更多实验

实验名称：Antiviral activity against thymidine kinase deficient herpes simplex virus; active 来源：ChEMBL 靶标：Human alphaherpesvirus 2 External Id：CHEMBL696294

实验名称：Duration of time of healing period in HSV-1 cutaneous infection in guinea pig at 1% H... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL687502

实验名称：Duration of time of healing period in HSV-1 cutaneous infection in guinea pig at 0.1%... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL687501

实验名称：Duration of time of healing period in HSV-1 cutaneous infection in guinea pig at 5% H... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL687503

实验名称：Duration of time of lesion formation in HSV-1 cutaneous infection in guinea pig at 1%... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL686704

实验名称：Duration of time of lesion formation in HSV-1 cutaneous infection in guinea pig at 0.... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL687505

实验名称：Selectivity index, ratio of CC50 for HFF cells to EC50 for Vaccinia virus WR infected... 来源：ChEMBL 靶标：N/A External Id：CHEMBL855404

实验名称：Duration of time of lesion formation in HSV-1 cutaneous infection in guinea pig at 5%... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL686705

实验名称：Selectivity index, ratio of CC50 for HFF cells to EC50 for Cowpox virus Brighton infe... 来源：ChEMBL 靶标：N/A External Id：CHEMBL855406

实验名称：Selectivity index, ratio of CC50 for HFF cells to EC50 for Vaccinia virus Copenhagen ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL855402

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西多福韦英文别名

• Cidofovir hydrate (1:2)
• Gs-0504
• Cidofovir dihydrate
• ({[(2S)-1-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
• Cidofovir
• (S)-[[2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic Acid
• Unii-jil713Q00n
• (S)-HPMPC Hydrate
• Cidovir Hydrate
• Vistide Hydrate
• (S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl-1-(hydroxymethyl)ethoxy)methyl phosphonic acid
• ({[(2S)-1-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-3-hydroxy-2-propanyl]oxy}methyl)phosphonic acid
• Vistide
• Drg-0145
• Cidofovir hydrate
• GS 0504 Hydrate
• Cidofovir (dihydrate)