LOE 908 HYDROCHLORIDE

Modify Date: 2024-01-10 09:47:28

LOE 908 HYDROCHLORIDE Structure
LOE 908 HYDROCHLORIDE structure
Common Name LOE 908 HYDROCHLORIDE
CAS Number 149759-26-2 Molecular Weight 749.28900
Density 1.17g/cm3 Boiling Point 803.7ºC at 760mmHg
Molecular Formula C41H49ClN2O9 Melting Point N/A
MSDS N/A Flash Point 439.9ºC

 Use of LOE 908 HYDROCHLORIDE


Pinokalant is a broad-spectrum and non-selectivecation channel inhibitor. Pinokalant significantly reduces cortical infarct volume. Pinokalant o improves the metabolic and electrophysiologic status of the ischemic penumbra. Pinokalant reduces lesion size on magnetic resonance images in the acute phase following middle cerebral artery occlusion in rats. Pinokalant has the potential for the research of stroke. Pinokalant also shows anti-SARS-CoV-2 activity[1].

 Names

Name 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)-2-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]acetamide
Synonym More Synonyms

 LOE 908 HYDROCHLORIDE Biological Activity

Description Pinokalant is a broad-spectrum and non-selectivecation channel inhibitor. Pinokalant significantly reduces cortical infarct volume. Pinokalant o improves the metabolic and electrophysiologic status of the ischemic penumbra. Pinokalant reduces lesion size on magnetic resonance images in the acute phase following middle cerebral artery occlusion in rats. Pinokalant has the potential for the research of stroke. Pinokalant also shows anti-SARS-CoV-2 activity[1].
Related Catalog
In Vivo Pinokalant significantly reduces cortical infarct volume from 33.8 mm3 to 24.5 mm3[1].
References

[1]. Christensen T, et al. The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):316-24.

[2]. Simard JM, et al. Non-selective cation channels, transient receptor potential channels and ischemic stroke. Biochim Biophys Acta. 2007 Aug;1772(8):947-57.

[3]. Serdar Durdagi, et al. Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike Receptor-Binding Domain Bound with ACE2 COVID19 Target Proteins: A Virtual Drug Repurposing Study. 2020.

 Chemical & Physical Properties

Density 1.17g/cm3
Boiling Point 803.7ºC at 760mmHg
Molecular Formula C41H49ClN2O9
Molecular Weight 749.28900
Flash Point 439.9ºC
Exact Mass 748.31300
PSA 106.51000
LogP 6.43600
Vapour Pressure 7.33E-26mmHg at 25°C
Index of Refraction 1.561

 Synonyms

unii-7j9zz971ao
pinokalant
loe 908
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