LOE 908 HYDROCHLORIDE

• 常用名: LOE 908 HYDROCHLORIDE
• 英文名: LOE 908 HYDROCHLORIDE
• CAS号: 149759-26-2
• 分子量: 749.28900
• 密度: 1.17g/cm3
• 沸点: 803.7ºC at 760mmHg
• 分子式: C₄₁H₄₉ClN₂O₉
• 熔点: N/A
• 闪点: 439.9ºC

LOE 908 HYDROCHLORIDE用途

匹诺卡兰是一种广谱非选择性通道抑制剂。匹诺卡兰显著减少皮层梗死体积。匹诺卡兰o改善缺血半暗带的代谢和电生理状态。匹诺卡兰在大鼠大脑中动脉阻塞后的急性期减少磁共振图像上的病灶大小。皮诺卡兰具有研究中风的潜力。匹诺卡兰还显示出抗SARS-CoV-2活性[1]。

LOE 908 HYDROCHLORIDE名称

• 英文名: 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)-2-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]acetamide

LOE 908 HYDROCHLORIDE生物活性

• 描述: 匹诺卡兰是一种广谱非选择性通道抑制剂。匹诺卡兰显著减少皮层梗死体积。匹诺卡兰o改善缺血半暗带的代谢和电生理状态。匹诺卡兰在大鼠大脑中动脉阻塞后的急性期减少磁共振图像上的病灶大小。皮诺卡兰具有研究中风的潜力。匹诺卡兰还显示出抗SARS-CoV-2活性[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  信号通路 >> 抗感染 >> SARS冠状病毒
  研究领域 >> 神经疾病
• 体内研究: 匹诺卡兰显著减少皮质梗死体积,从33.8 mm3减少到24.5 mm3[1]。
• 参考文献:

  [1]. Christensen T, et al. The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):316-24.

  [2]. Simard JM, et al. Non-selective cation channels, transient receptor potential channels and ischemic stroke. Biochim Biophys Acta. 2007 Aug;1772(8):947-57.

  [3]. Serdar Durdagi, et al. Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike Receptor-Binding Domain Bound with ACE2 COVID19 Target Proteins: A Virtual Drug Repurposing Study. 2020.

LOE 908 HYDROCHLORIDE物理化学性质

• 密度: 1.17g/cm3
• 沸点: 803.7ºC at 760mmHg
• 分子式: C₄₁H₄₉ClN₂O₉
• 分子量: 749.28900
• 闪点: 439.9ºC
• 精确质量: 748.31300
• PSA: 106.51000
• LogP: 6.43600
• InChIKey: PYWYBTRACMRUQV-UHFFFAOYSA-N
• SMILES: COc1cc2c(cc1OC)C(C(C(=O)N(CCc1ccc(OC)c(OC)c1OC)CCc1ccc(OC)c(OC)c1OC)c1ccccc1)=NCC2
• 蒸汽压: 7.33E-26mmHg at 25°C
• 折射率: 1.561

LOE 908 HYDROCHLORIDE靶点实验

查看更多实验

实验名称：qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1):... 来源：NCGC 靶标：thioredoxin reductase [Rattus norvegicus] External Id：TRXR101

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实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：S16 Schwann cell PMP22 intronic element firefly luciferase assay 来源：NCGC 靶标：peripheral myelin protein 22 [Rattus norvegicus] External Id：cmt-p4-fluc-fda_regid

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1):... 来源：NCGC 靶标：thioredoxin reductase [Rattus norvegicus] External Id：TRXR100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary ... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2Venus

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

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LOE 908 HYDROCHLORIDE英文别名

• unii-7j9zz971ao
• pinokalant
• loe 908