Gca-186

Modify Date: 2024-01-13 19:33:01

Gca-186 Structure
Gca-186 structure
Common Name Gca-186
CAS Number 149950-61-8 Molecular Weight 330.42
Density N/A Boiling Point N/A
Molecular Formula C19H26N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Gca-186


GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].

 Names

Name GCA-186

 Gca-186 Biological Activity

Description GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].
Related Catalog
In Vitro GCA-186 shows antiviral activity (EC50=0.6 nM) and cytotoxicity against HIV-1 in MT-4 cells (CC50=43 μM)[2].
References

[1]. El-Brollosy NR, et al. Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186. Arch Pharm (Weinheim). 2008;341(1):9-19.

[2]. Hopkins AL, et al. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J Med Chem. 1999;42(22):4500-4505.

 Chemical & Physical Properties

Molecular Formula C19H26N2O3
Molecular Weight 330.42
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.