Gca-186

Modify Date: 2024-01-13 19:33:01

Gca-186 structure	Common Name	Gca-186
	CAS Number	149950-61-8	Molecular Weight	330.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₆N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Gca-186

GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].

Name	GCA-186

Description	GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
In Vitro	GCA-186 shows antiviral activity (EC50=0.6 nM) and cytotoxicity against HIV-1 in MT-4 cells (CC50=43 μM)[2].
References	[1]. El-Brollosy NR, et al. Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186. Arch Pharm (Weinheim). 2008;341(1):9-19. [2]. Hopkins AL, et al. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J Med Chem. 1999;42(22):4500-4505.

Molecular Formula	C₁₉H₂₆N₂O₃
Molecular Weight	330.42

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GCA-186
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Gca-186
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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