Gca-186

Modify Date: 2024-01-13 19:33:01

Gca-186 Structure
Gca-186 structure
 Common Name Gca-186
CAS Number 149950-61-8 Molecular Weight 330.42
Density N/A Boiling Point N/A
Molecular Formula C19H26N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Gca-186


GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].

 Names

Name GCA-186

 Gca-186 Biological Activity

Description GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].
Related Catalog
In Vitro GCA-186 shows antiviral activity (EC50=0.6 nM) and cytotoxicity against HIV-1 in MT-4 cells (CC50=43 μM)[2].
References

[1]. El-Brollosy NR, et al. Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186. Arch Pharm (Weinheim). 2008;341(1):9-19.

[2]. Hopkins AL, et al. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J Med Chem. 1999;42(22):4500-4505.

 Chemical & Physical Properties

Molecular Formula C19H26N2O3
Molecular Weight 330.42
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Chemsrc provides Gca-186(CAS#:149950-61-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Gca-186 are included as well.>> amp version: Gca-186

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