Prasugrel structure
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Common Name | Prasugrel | ||
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CAS Number | 150322-43-3 | Molecular Weight | 373.44100 | |
Density | 1.347 | Boiling Point | 493.5ºC at 760 mmHg | |
Molecular Formula | C20H20FNO3S | Melting Point | 122 °C | |
MSDS | Chinese USA | Flash Point | 252.3ºC |
Use of PrasugrelPrasugrel is a platelet inhibitor with IC50 value of 1.8 μM.IC50 value:Target: P2Y12 receptorPrasugrel is a novel platelet inhibitor used for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI. Prasugrel reduces the aggregation ("clumping") of platelets by irreversibly binding to P2Y12 receptors. In rat platelets, prasugrel AM inhibited in vitro platelet aggregation induced by ADP (10 μm) with an IC50 value of 1.8 μm. From Wikipedia |
Name | Prasugrel |
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Synonym | More Synonyms |
Description | Prasugrel is a platelet inhibitor with IC50 value of 1.8 μM.IC50 value:Target: P2Y12 receptorPrasugrel is a novel platelet inhibitor used for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI. Prasugrel reduces the aggregation ("clumping") of platelets by irreversibly binding to P2Y12 receptors. In rat platelets, prasugrel AM inhibited in vitro platelet aggregation induced by ADP (10 μm) with an IC50 value of 1.8 μm. From Wikipedia |
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Related Catalog | |
References |
[3]. Darius H.Prasugrel.Hamostaseologie. 2012 Aug 1;32(3):186-90. |
Density | 1.347 |
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Boiling Point | 493.5ºC at 760 mmHg |
Melting Point | 122 °C |
Molecular Formula | C20H20FNO3S |
Molecular Weight | 373.44100 |
Flash Point | 252.3ºC |
Exact Mass | 373.11500 |
PSA | 74.85000 |
LogP | 3.82890 |
Vapour Pressure | 0mmHg at 25°C |
Index of Refraction | 1.619 |
Storage condition | 2-8°C |
Hazard Codes | Xi |
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RIDADR | NONH for all modes of transport |
Precursor 9 | |
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DownStream 0 |
Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase.
PLoS ONE 9(10) , e110054, (2014) Homocysteinylation of lysine residues by homocysteine thiolactone (HCTL), a reactive homocysteine metabolite, results in protein aggregation and malfunction, and is a well-known risk factor for cardio... |
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Effect of grapefruit juice on the bioactivation of prasugrel.
Br. J. Clin. Pharmacol. 80 , 139-45, (2015) The P2Y12 inhibitor prasugrel is a prodrug, which is activated after its initial hydrolysis partly by cytochrome P450 (CYP) 3A4. Grapefruit juice, a strong inactivator of intestinal CYP3A4, greatly re... |
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Safety of short-term dual antiplatelet therapy after drug-eluting stents: An updated meta-analysis with direct and adjusted indirect comparison of randomized control trials.
Int. J. Cardiol. 181 , 331-9, (2015) Duration of dual antiplatelet therapy (DAPT) following drug-eluting stents (DES) remains controversial and is a topic of ongoing research.Direct and adjusted indirect comparisons of all the recent ran... |
5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate |
Prasugrel |
Ethanone, 2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)- |
Unii-34K66tbt99 |
Effient |
Efient |