Moxifloxacin

Modify Date: 2025-08-20 20:01:08

Moxifloxacin Structure
Moxifloxacin structure
 Common Name Moxifloxacin
CAS Number 151096-09-2 Molecular Weight 401.43
Density 1.4±0.1 g/cm3 Boiling Point 636.4±55.0 °C at 760 mmHg
Molecular Formula C21H24FN3O4 Melting Point 193-195 °C(lit.)
MSDS N/A Flash Point 338.7±31.5 °C

 Use of Moxifloxacin


Moxifloxacin is a synthetic fluoroquinolone antibiotic agent.Target: AntibacterialMoxifloxacin is an extended-spectrum fluoroquinolone which has improved coverage against gram-positive cocci and atypical pathogens compared with older fluoroquinolone agents, while retaining good activity against gram-negative bacteria. The antibacterial spectrum of moxifloxacin includes all major upper and lower respiratory tract pathogens; it is one of the most active fluoroquinolones against pneumococci, including penicillin- and macrolide-resistant strains [1]. Moxifloxacin has limited phototoxic potential. In clinical trials, moxifloxacin had clinical success rates of 88-97% and bacteriologic eradication rates of 90-97%. Moxifloxacin is a safe and effective antimicrobial that will be useful for treating acute sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia [2]. Moxifloxacin possibly stimulates lipid peroxidation and enhances phagocytosis, as depicted by MDA production and survival prolongation, without being toxic as depicted by white blood cell count [3]. Clinical indications: Abdominal abscess; Acute bronchitis; Acute sinusitis; Bacterial infectionToxicity: Symptoms of overdose include CNS and gastrointestinal effects such as decreased activity, somnolence, tremor, convulsions, vomiting, and diarrhea. The minimal lethal intravenous dose in mice and rats is 100 mg/kg.

 Names

Name moxifloxacin
Synonym More Synonyms

 Moxifloxacin Biological Activity

Description Moxifloxacin is a synthetic fluoroquinolone antibiotic agent.Target: AntibacterialMoxifloxacin is an extended-spectrum fluoroquinolone which has improved coverage against gram-positive cocci and atypical pathogens compared with older fluoroquinolone agents, while retaining good activity against gram-negative bacteria. The antibacterial spectrum of moxifloxacin includes all major upper and lower respiratory tract pathogens; it is one of the most active fluoroquinolones against pneumococci, including penicillin- and macrolide-resistant strains [1]. Moxifloxacin has limited phototoxic potential. In clinical trials, moxifloxacin had clinical success rates of 88-97% and bacteriologic eradication rates of 90-97%. Moxifloxacin is a safe and effective antimicrobial that will be useful for treating acute sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia [2]. Moxifloxacin possibly stimulates lipid peroxidation and enhances phagocytosis, as depicted by MDA production and survival prolongation, without being toxic as depicted by white blood cell count [3]. Clinical indications: Abdominal abscess; Acute bronchitis; Acute sinusitis; Bacterial infectionToxicity: Symptoms of overdose include CNS and gastrointestinal effects such as decreased activity, somnolence, tremor, convulsions, vomiting, and diarrhea. The minimal lethal intravenous dose in mice and rats is 100 mg/kg.
Related Catalog
References

[1]. Balfour, J.A. and H.M. Lamb, Moxifloxacin: a review of its clinical potential in the management of community-acquired respiratory tract infections. Drugs, 2000. 59(1): p. 115-39.

[2]. Culley, C.M., et al., Moxifloxacin: clinical efficacy and safety. Am J Health Syst Pharm, 2001. 58(5): p. 379-88.

[3]. Ioannidis, O., et al., Effect of moxifloxacin on the survival, lipid peroxidation and inflammation of immunosuppressed rats with soft tissue infection from Stenotrophomonas maltophilia. Microbiol Immunol, 2013.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 636.4±55.0 °C at 760 mmHg
Melting Point 193-195 °C(lit.)
Molecular Formula C21H24FN3O4
Molecular Weight 401.43
Flash Point 338.7±31.5 °C
PSA 83.80000
LogP 1.60
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.633

 Safety Information

Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S26-S37/39
WGK Germany 3
HS Code 29329970

 Synthetic Route

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid structure

1-Cyclopropyl-6...

CAS#:112811-72-0

(S,S)-2,8-Diazabicyclo[4,3,0]nonane structure

(S,S)-2,8-Diaza...

CAS#:151213-40-0

~89%

Moxifloxacin Structure

Moxifloxacin

CAS#:151096-09-2

Literature: SANDOZ AG Patent: EP1992626 A1, 2008 ; Location in patent: Page/Page column 10 ;
Moxifloxacin HCl structure

Moxifloxacin HCl

CAS#:186826-86-8

~%

Moxifloxacin Structure

Moxifloxacin

CAS#:151096-09-2

Literature: WO2008/59521 A2, ; Page/Page column 26 ;
N/A structure

N/A

CAS#:1028205-69-7

~%

Moxifloxacin Structure

Moxifloxacin

CAS#:151096-09-2

Literature: WO2008/59521 A2, ; Page/Page column 23 ;
N/A structure

N/A

CAS#:1028205-70-0

~%

Moxifloxacin Structure

Moxifloxacin

CAS#:151096-09-2

Literature: WO2008/59521 A2, ; Page/Page column 23 ;
(4aS,7aS)-tert-butyl 6-(1-cyclopropyl-3-(diethylcarbamoyl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinolin-7-yl)octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate structure

(4aS,7aS)-tert-...

CAS#:1028205-71-1

~%

Moxifloxacin Structure

Moxifloxacin

CAS#:151096-09-2

Literature: WO2008/59521 A2, ; Page/Page column 23 ;
1-cyclopropyl-6-fluoro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxamide structure

1-cyclopropyl-6...

CAS#:1028205-72-2

~%

Moxifloxacin Structure

Moxifloxacin

CAS#:151096-09-2

Literature: WO2008/59521 A2, ; Page/Page column 22; 23-24 ;
N/A structure

N/A

CAS#:496919-99-4

(S,S)-2,8-Diazabicyclo[4,3,0]nonane structure

(S,S)-2,8-Diaza...

CAS#:151213-40-0

~%

Moxifloxacin Structure

Moxifloxacin

CAS#:151096-09-2

Literature: WO2008/59223 A2, ; Page/Page column 15-16 ;
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid structure

1-Cyclopropyl-6...

CAS#:112811-72-0

~%

Moxifloxacin Structure

Moxifloxacin

CAS#:151096-09-2

Literature: US5480879 A1, ;
(E)-ethyl 3-(cyclopropylamino)-2-(2,4,5- trifluoro-3-methoxybenzoyl)acrylate structure

(E)-ethyl 3-(cy...

CAS#:112811-70-8

~%

Moxifloxacin Structure

Moxifloxacin

CAS#:151096-09-2

Literature: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 121, p. 254 - 258

 Customs

HS Code 29329970

 Synonyms

1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
1-Cyclopropyl-6-fluoro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic Acid
MAXIOFFOXACIN
BAY 12-8039
1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Moxifloxacin
Moxeza
Avdox
Vigamox
Avelox
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-
Avalox
MFCD04117996
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