Penehyclidine hydrochloride

Modify Date: 2024-01-07 15:04:12

Penehyclidine hydrochloride Structure
Penehyclidine hydrochloride structure
Common Name Penehyclidine hydrochloride
CAS Number 151937-76-7 Molecular Weight 351.91100
Density N/A Boiling Point 461ºC at 760 mmHg
Molecular Formula C20H30ClNO2 Melting Point N/A
MSDS N/A Flash Point 232.6ºC

 Use of Penehyclidine hydrochloride


Penehyclidine (Penequinine) hydrochloride, a anticholinergic drug, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1].

 Names

Name 2-(1-azabicyclo[2.2.2]octan-3-yloxy)-1-cyclopentyl-1-phenylethanol,hydrochloride
Synonym More Synonyms

 Penehyclidine hydrochloride Biological Activity

Description Penehyclidine (Penequinine) hydrochloride, a anticholinergic drug, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1].
Related Catalog
Target

NF-κB

References

[1]. Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885.

 Chemical & Physical Properties

Boiling Point 461ºC at 760 mmHg
Molecular Formula C20H30ClNO2
Molecular Weight 351.91100
Flash Point 232.6ºC
Exact Mass 351.19700
PSA 32.70000
LogP 3.91510
Vapour Pressure 2.71E-09mmHg at 25°C
Storage condition -20°C

 Synonyms

Penequine hydrochloride
2-(1-azabicyclo[2.2.2]oct-3-yloxy)-1-cyclopentyl-1-phenylethanol hydrochloride (1:1)
Penehyclidine hydrochloride
Penequinine
2-(1-azabicyclo[2.2.2]octan-3-yloxy)-1-cyclopentyl-1-phenylethanol hydrochloride
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