benzyloxycarbonylleucyl-leucyl-leucyl-4-methyl-coumaryl-7-amide

Modify Date: 2024-07-24 19:31:54

benzyloxycarbonylleucyl-leucyl-leucyl-4-methyl-coumaryl-7-amide Structure
benzyloxycarbonylleucyl-leucyl-leucyl-4-methyl-coumaryl-7-amide structure
Common Name benzyloxycarbonylleucyl-leucyl-leucyl-4-methyl-coumaryl-7-amide
CAS Number 152015-61-7 Molecular Weight 648.78900
Density 1.174g/cm3 Boiling Point 854.4ºC at 760mmHg
Molecular Formula C36H48N4O7 Melting Point N/A
MSDS N/A Flash Point 470.5ºC

 Use of benzyloxycarbonylleucyl-leucyl-leucyl-4-methyl-coumaryl-7-amide


Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome[1].

 Names

Name benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Synonym More Synonyms

  Biological Activity

Description Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome[1].
Related Catalog
References

[1]. McNaught KS, et al. Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci Lett. 2001 Jan 19;297(3):191-4.  

 Chemical & Physical Properties

Density 1.174g/cm3
Boiling Point 854.4ºC at 760mmHg
Molecular Formula C36H48N4O7
Molecular Weight 648.78900
Flash Point 470.5ºC
Exact Mass 648.35200
PSA 166.31000
LogP 7.40080
Vapour Pressure 1.63E-29mmHg at 25°C
Index of Refraction 1.561

 Synonyms

Zlll-mca
Z-Leu-leu-leu-4-methylcoumaryl-7-amide
Benzyloxycarbonylleucyl-leucyl-leucyl-4-methyl-coumaryl-7-amide
L-Leucinamide,N-((phenylmethoxy)carbonyl)-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)