Xanomeline tartrate
Modify Date: 2024-01-09 16:13:47
Xanomeline tartrate structure
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Common Name | Xanomeline tartrate | ||
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| CAS Number | 152854-19-8 | Molecular Weight | 431.50400 | |
| Density | N/A | Boiling Point | 397ºC at 760 mmHg | |
| Molecular Formula | C18H29N3O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 193.9ºC | |
Use of Xanomeline tartrateXanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia[1][2][3]. |
| Name | (2R,3R)-2,3-dihydroxybutanedioic acid,3-hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole |
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| Synonym | More Synonyms |
| Description | Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia[1][2][3]. |
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| Related Catalog | |
| Target |
M1/M4[1] |
| In Vitro | Xanomeline (LY 246708) (0.1-10 μM; CNS4U) shows an overall increase in the mean firing rate. Xanomeline (LY 246708) shows the M1 receptor is functional in hiPSC derived neurons. Xanomeline (LY 246708) (＞1 μM) has a prolonged engagement with the receptor and produces a persistent receptor activation leading to a sustained suppression of the M-current[1]. |
| In Vivo | Xanomeline (LY 246708) (0.5-3 mg/kg; s.c.; 1-3 hours) induces salivation and vomiting in some monkeys[3]. Xanomeline (LY 246708) shows functional dopamine antagonism and an antipsychotic-like profile[3]. Xanomeline (LY 246708) inhibits D-amphetamine- and (−)-apomorphine-induced behavior and do not cause extrapyramidal side effects[3]. Animal Model: Male Cebus apella monkeys[3] Dosage: 0.5-3 mg/kg Administration: s.c.; 1-3 hours Result: Induced salivation and vomiting in some monkeys. |
| References |
| Boiling Point | 397ºC at 760 mmHg |
|---|---|
| Molecular Formula | C18H29N3O7S |
| Molecular Weight | 431.50400 |
| Flash Point | 193.9ºC |
| Exact Mass | 431.17300 |
| PSA | 181.55000 |
| LogP | 1.03140 |
| Vapour Pressure | 1.64E-06mmHg at 25°C |
| Memcor |
| Xanomeline tartrate (USAN) |
| Xanomeline tartrate |