Isolithocholic Acid

Modify Date: 2024-01-11 23:11:20

Isolithocholic Acid structure	Common Name	Isolithocholic Acid
	CAS Number	1534-35-6	Molecular Weight	376.57
	Density	1.1±0.1 g/cm3	Boiling Point	511.0±23.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₄₀O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	276.9±19.1 °C

Use of Isolithocholic Acid

Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate[1][2].

Name	Isolithocholic Acid
Synonym	More Synonyms

Description	Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate[1][2].
Related Catalog	Research Areas >> Endocrinology
Target	Microbial Metabolite
In Vitro	Isolithocholic acid at 0.01 % does not inhibit spore germination and outgrowth of CF5 and M120, but it significantly inhibits at the higher concentration (0.1 %). Isolithocholic acid (0.00003 %) prevents growth of CD196, M68, CF5, 630, and BI9 and significant decreases strains CF5, BI9, M120, and 630 in toxin activity. Isolithocholic acid (0.0003 %) makes that all strains displays a significant decrease in toxin activity, except for R20291 and M120[3].
In Vivo	The levels of fecal Isolithocholic acid shows obvious decreases from day 28 onward in the high fat diet (HFD) group compared with rats fed a normal diet[4].
References	[1]. Batta AK, et al. Transformation of bile acids into iso-bile acids by Clostridium perfringens: possible transport of 3 beta-hydrogen via the coenzyme. Hepatology. 1985;5(6):1126-1131. [2]. Borriello SP, et al. The metabolism of lithocholic acid and lithocholic acid-3-alpha-sulfate by human fecal bacteria. Lipids. 1982;17(7):477-482. [3]. Thanissery R, et al. Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids. Anaerobe. 2017;45:86-100. [4]. Lin H, et al. Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model. J Agric Food Chem. 2019;67(13):3624-3632.

Density	1.1±0.1 g/cm3
Boiling Point	511.0±23.0 °C at 760 mmHg
Molecular Formula	C₂₄H₄₀O₃
Molecular Weight	376.57
Flash Point	276.9±19.1 °C
Exact Mass	376.297760
LogP	6.70
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.528
Storage condition	2-8 °C

3b-Hydroxy-5b-cholan-24-oic acid

3b-Lithocholic acid

3β-Hydroxy-5β-cholan-24-oic Acid

Cholan-24-oic acid, 3-hydroxy-, (3β,5β)-

Isolithocholic acid

(3β,5β)-3-Hydroxycholan-24-oic acid

(3β,5β,20R)-3-Hydroxycholan-24-oic acid

(3Î²,5Î²)-3-hydroxy-cholan-24-oic acid

Cholan-24-oic acid, 3-hydroxy-, (3β,5β,20R)-

MFCD00271385

Isolithocholic Acid

Use of Isolithocholic Acid

Names

Isolithocholic Acid Biological Activity

Chemical & Physical Properties

Synonyms