Plevitrexed
Modify Date: 2024-01-30 09:32:59
Plevitrexed structure
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Common Name | Plevitrexed | ||
|---|---|---|---|---|
| CAS Number | 153537-73-6 | Molecular Weight | 532.52600 | |
| Density | 1.44g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H25FN8O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PlevitrexedPlevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical[1][2][3]. |
| Name | Plevitrexed |
|---|---|
| Synonym | More Synonyms |
| Description | Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical[1][2][3]. |
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| Related Catalog | |
| In Vitro | ZD9331 inhibits the transport of [3H]-methotrexate into L1210 and W1L2 cells with a Ki of∼1 µM[3]. |
| References |
| Density | 1.44g/cm3 |
|---|---|
| Molecular Formula | C26H25FN8O4 |
| Molecular Weight | 532.52600 |
| Exact Mass | 532.19800 |
| PSA | 169.85000 |
| LogP | 2.03860 |
| Index of Refraction | 1.683 |
| (2S)-2-((4-(((2,7-Dimethyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)(prop-2-ynyl)amino)-2-fluorobenzoyl)amino)-4-(1H-tetrazol-5-yl)butanoic acid |
| Vamidex |
| BGC 9331 |
| (aS)-a-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid |
| ZD 9331 |
| FLUOROBENZAMIDO)-4-(1H-TETRAZOL-5-YL)BUTYRIC ACID |