Atreleuton

Modify Date: 2026-07-01 19:07:03

Atreleuton structure	Common Name	Atreleuton
	CAS Number	154355-76-7	Molecular Weight	318.36600
	Density	1.37g/cm3	Boiling Point	506.7ºC at 760mmHg
	Molecular Formula	C₁₆H₁₅FN₂O₂S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	260.2ºC
	Symbol	GHS07	Signal Word	Warning

Use of Atreleuton

Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation[1][2][3].

Name	1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea
Synonym	More Synonyms

Description	Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	5-LO[1]
References	[1]. VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease. VIA Pharmaceuticals, Inc. [2]. Reid JJ, et al. ABT-761 (Abbott). Curr Opin Investig Drugs. 2001 Jan;2(1):68-71. [3]. Bell RL, et al. ABT-761 attenuates bronchoconstriction and pulmonary inflammation in rodents. J Pharmacol Exp Ther. 1997 Mar;280(3):1366-73.

Density	1.37g/cm3
Boiling Point	506.7ºC at 760mmHg
Molecular Formula	C₁₆H₁₅FN₂O₂S
Molecular Weight	318.36600
Flash Point	260.2ºC
Exact Mass	318.08400
PSA	95.79000
LogP	3.50170
Vapour Pressure	4.34E-11mmHg at 25°C
Index of Refraction	1.652
InChIKey	MMSNEKOTSJRTRI-LLVKDONJSA-N
SMILES	CC(C#Cc1ccc(Cc2ccc(F)cc2)s1)N(O)C(N)=O

Atreleuton MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

5-((4-fluorophe...

CAS#:154355-88-1

(R)-(+)-N-hydro...

CAS#:154355-92-7

~17%

Atreleuton

CAS#:154355-76-7

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Literature: Brooks; Stewart; Basha; Bhatia; Ratajczyk; Martin; Craig; Kolasa; Bouska; Lanni; Harris; Malo; Carter; Bell Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4768 - 4775

4-Fluorobenzyl ...

CAS#:459-46-1

Atreleuton

CAS#:154355-76-7

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Literature: Brooks; Stewart; Basha; Bhatia; Ratajczyk; Martin; Craig; Kolasa; Bouska; Lanni; Harris; Malo; Carter; Bell Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4768 - 4775

2-(4-FLUOROBENZ...

CAS#:63877-96-3

Atreleuton

CAS#:154355-76-7

Learn More

Literature: Brooks; Stewart; Basha; Bhatia; Ratajczyk; Martin; Craig; Kolasa; Bouska; Lanni; Harris; Malo; Carter; Bell Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4768 - 4775

Name: Oral bioavailability was determined in guinea pig
Source: ChEMBL
Target: N/A
External Id: CHEMBL629642

Name: Oral bioavailability was determined in mouse
Source: ChEMBL
Target: N/A
External Id: CHEMBL629644

Name: Oral bioavailability in rat
Source: ChEMBL
Target: N/A
External Id: CHEMBL629645

Name: Compound was tested for in vivo inhibition against rat peritoneal anaphylaxis.
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL782430

Name: t1/2 in monkey after PO dose (2 umol/kg)
Source: ChEMBL
Target: N/A
External Id: CHEMBL633211

Name: Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood ...
Source: ChEMBL
Target: Polyunsaturated fatty acid 5-lipoxygenase
External Id: CHEMBL701321

Name: Inhibitory activity against 5-lipoxygenase obtained from rat basophilic leukemia cell...
Source: ChEMBL
Target: Polyunsaturated fatty acid 5-lipoxygenase
External Id: CHEMBL619225

Name: Compound was evaluated in vivo for the rat anaphylaxis leukotriene formation at an or...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL785430

Name: Rate of glucuronidation was determined using a microsomal preparation from the monkey...
Source: ChEMBL
Target: Cercopithecidae
External Id: CHEMBL730815

Name: phase 1 oral half life at a dose 200 mg. (200 mg provided >95% inhibition of ex vivo ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL637753

Total 27, Current Page 1 of 3

[14C]-Atreleuton

(R)-N-(3-(5-(4-fluorophenylmethyl)-2-thienyl)-1-methyl-2-propynyl)-N-hydroxyurea

Atreleuton [USAN]

Atreleuton

ABT-761

Atreleuton (USAN/INN)

UNII-U301T88E1M

(R)-N-{3-[5-(4-fluorophenylmethyl)-thien-2-yl]-1-methyl-2-propynyl}-N-hydroxyurea

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Atreleuton
Price: Check
Purity: 95.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxy-urea
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.