APC-6860

Modify Date: 2025-08-25 16:03:41

APC-6860 structure	Common Name	APC-6860
	CAS Number	154628-42-9	Molecular Weight	302.13500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉H₇IN₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of APC-6860

APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer[1][2].

Name	4-iodo-1-benzothiophene-2-carboximidamide
Synonym	More Synonyms

Description	APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer
Target	uPA:0.21 μM (Ki) trypsin:0.44 μM (Ki) tryptase:1.5 μM (Ki) tPA:16.8 μM (Ki) thrombin:20 μM (Ki) factor Xa:30 μM (Ki) human urokinases:0.1 μM (Ki) murine urokinases:0.082 μM (Ki)
In Vitro	APC-6860 (compound 2) inhibits urokinases in MiaPaCa-2 and Lewis Lung Carcinoma cells with IC50s of 1.4 and 3.1 μM, respectively[2].
References	[1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. [2]. Klinghofer V, et al. Species specificity of amidine-based urokinase inhibitors. Biochemistry. 2001 Aug 7;40(31):9125-31.

Molecular Formula	C₉H₇IN₂S
Molecular Weight	302.13500
Exact Mass	301.93700
PSA	78.11000
LogP	3.59000

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: APC-6860
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: APC-6860
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.