Inosine,2-chloro-6-O-methyl- (9CI)

Modify Date: 2024-01-24 14:03:34

Inosine,2-chloro-6-O-methyl- (9CI) structure	Common Name	Inosine,2-chloro-6-O-methyl- (9CI)
	CAS Number	15465-92-6	Molecular Weight	316.70
	Density	1.95g/cm3	Boiling Point	587.8ºC at 760mmHg
	Molecular Formula	C₁₁H₁₃ClN₄O₅	Melting Point	140 °C(Solv: isopropanol (67-63-0))
	MSDS	N/A	Flash Point	309.3ºC

Use of Inosine,2-chloro-6-O-methyl- (9CI)

2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

Name	2-Chloro-6-O-methyl-inosine
Synonym	More Synonyms

Description	2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. [2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

References

[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.

[2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

Density	1.95g/cm3
Boiling Point	587.8ºC at 760mmHg
Melting Point	140 °C(Solv: isopropanol (67-63-0))
Molecular Formula	C₁₁H₁₃ClN₄O₅
Molecular Weight	316.70
Flash Point	309.3ºC
Exact Mass	316.05700
PSA	122.75000
Vapour Pressure	1.16E-14mmHg at 25°C
Index of Refraction	1.784

Sodium Methylate

CAS#:124-41-4

Inosine,2-chlor...

CAS#:15465-92-6

Literature: Schaeffer; Thomas Journal of the American Chemical Society, 1958 , vol. 80, p. 3738,3741

Precursor 1
CAS#:124-41-4 Sodium Methylate
DownStream 5
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