Tamoxifen-d5

Modify Date: 2024-01-11 18:46:23

Tamoxifen-d5 Structure
Tamoxifen-d5 structure
Common Name Tamoxifen-d5
CAS Number 157698-32-3 Molecular Weight 376.54500
Density 1.057g/cm3 Boiling Point 482.3ºC at 760mmHg
Molecular Formula C26H24D5NO Melting Point N/A
MSDS N/A Flash Point 140ºC

 Use of Tamoxifen-d5


Tamoxifen-d5 (ICI 47699-d5) is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].

 Names

Name N,N-dimethyl-2-[4-[(Z)-3,3,4,4,4-pentadeuterio-1,2-diphenylbut-1-enyl]phenoxy]ethanamine
Synonym More Synonyms

 Tamoxifen-d5 Biological Activity

Description Tamoxifen-d5 (ICI 47699-d5) is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].
Related Catalog
Target

Estrogen receptor

HSP90

References

[1]. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18.

[2]. Zhao R, et al. Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. PLoS One. 2010 Apr 1;5(4):e9934.

 Chemical & Physical Properties

Density 1.057g/cm3
Boiling Point 482.3ºC at 760mmHg
Molecular Formula C26H24D5NO
Molecular Weight 376.54500
Flash Point 140ºC
Exact Mass 376.25600
PSA 12.47000
LogP 5.99610
Vapour Pressure 1.85E-09mmHg at 25°C
Index of Refraction 1.582

 Synonyms

(E/Z)-Mammaton-d5
Novaldex-d5
Z-Tamoxifen-d5
Mammaton-d5
(E/Z)-Novaldex-d5
(E/Z)-Tamoxifen-d5
trans-Tamoxifen-d5
Tamoxifen-d5