GSK2983559 free acid

Modify Date: 2024-02-13 18:26:10

GSK2983559 free acid Structure
GSK2983559 free acid structure
Common Name GSK2983559 free acid
CAS Number 1579965-12-0 Molecular Weight 538.534
Density 1.5±0.1 g/cm3 Boiling Point 823.6±75.0 °C at 760 mmHg
Molecular Formula C21H23N4O7PS2 Melting Point N/A
MSDS N/A Flash Point 451.9±37.1 °C

 Use of GSK2983559 free acid


GSK2983559 free acid (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].

 Names

Name 2-({4-(1,3-Benzothiazol-5-ylamino)-6-[(2-methyl-2-propanyl)sulfonyl]-7-quinazolinyl}oxy)ethyl dihydrogen phosphate
Synonym More Synonyms

 GSK2983559 free acid Biological Activity

Description GSK2983559 free acid (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].
Target

RIP2[1]

References

[1]. Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. J Med Chem. 2019 Jul 25;62(14):6482-6494.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 823.6±75.0 °C at 760 mmHg
Molecular Formula C21H23N4O7PS2
Molecular Weight 538.534
Flash Point 451.9±37.1 °C
Exact Mass 538.074585
LogP 0.55
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.675

 Synonyms

2-({4-(1,3-Benzothiazol-5-ylamino)-6-[(2-methyl-2-propanyl)sulfonyl]-7-quinazolinyl}oxy)ethyl dihydrogen phosphate
Ethanol, 2-[[4-(5-benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]-, dihydrogen phosphate (ester)