Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate

Modify Date: 2024-01-02 18:08:11

Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate Structure
Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate structure
Common Name Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate
CAS Number 15854-11-2 Molecular Weight 277.33900
Density 1.233g/cm3 Boiling Point 424.2ºC at 760mmHg
Molecular Formula C14H15NO3S Melting Point 74ºC
MSDS N/A Flash Point 210.4ºC

 Names

Name ethyl 2-amino-4-(4-methoxyphenyl)thiophene-3-carboxylate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.233g/cm3
Boiling Point 424.2ºC at 760mmHg
Melting Point 74ºC
Molecular Formula C14H15NO3S
Molecular Weight 277.33900
Flash Point 210.4ºC
Exact Mass 277.07700
PSA 89.79000
LogP 3.76380
Vapour Pressure 2.1E-07mmHg at 25°C
Index of Refraction 1.596

 MSDS

Name: Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate Material Safety Data Sheet
Synonym: None Known
CAS: 15854-11-2
Section 1 - Chemical Product MSDS Name:Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate Material Safety Data Sheet
Synonym:None Known

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
15854-11-2 Ethyl 2-amino-4-(4-methoxyphenyl)-3-th 97+ unlisted
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 15854-11-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 74-78 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C14H15NO3S
Molecular Weight: 277.34

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
Oxidizing agents, acids, acid chlorides.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 15854-11-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 22 Do not breathe dust.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 15854-11-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 15854-11-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 15854-11-2 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases 36
Safety Phrases 26
HS Code 2934999090

 Synthetic Route

~46%

Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate Structure

Ethyl 2-amino-4...

CAS#:15854-11-2

Literature: Synlett, , # 16 p. 2559 - 2564

~1%

Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate Structure

Ethyl 2-amino-4...

CAS#:15854-11-2

Literature: WO2008/128072 A2, ; Page/Page column 37 ;

~%

Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate Structure

Ethyl 2-amino-4...

CAS#:15854-11-2

Literature: US2003/73733 A1, ; US 20030073733 A1

~%

Ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate Structure

Ethyl 2-amino-4...

CAS#:15854-11-2

Literature: Synthetic Communications, , vol. 37, # 23 p. 4273 - 4279

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

ethyl 2-amino-4-(4-methoxyphenyl)-3-thiophenecarboxylate
2-amino-3-carbethoxy-4-(4-methoxyphenyl)thiophene
ethyl 2-amino-4-(4-methoxyphenyl)-thiophene-3-carboxylate
2-amino-4-(4-methoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester
F0745-0325
MFCD01917484
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