2,6-dichloro-4-isocyanatopyridine

Modify Date: 2025-08-25 13:23:03

2,6-dichloro-4-isocyanatopyridine Structure
2,6-dichloro-4-isocyanatopyridine structure
Common Name 2,6-dichloro-4-isocyanatopyridine
CAS Number 159178-03-7 Molecular Weight 188.99900
Density 1.5g/cm3 Boiling Point 295.1ºC at 760mmHg
Molecular Formula C6H2Cl2N2O Melting Point N/A
MSDS USA Flash Point 132.3ºC

 Names

Name 2,6-dichloro-4-isocyanatopyridine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5g/cm3
Boiling Point 295.1ºC at 760mmHg
Molecular Formula C6H2Cl2N2O
Molecular Weight 188.99900
Flash Point 132.3ºC
Exact Mass 187.95400
PSA 42.32000
LogP 2.35570
Vapour Pressure 0.00156mmHg at 25°C
Index of Refraction 1.613
InChIKey OCDFIQXUCLQQHY-UHFFFAOYSA-N
SMILES O=C=Nc1cc(Cl)nc(Cl)c1

 MSDS

Name: 2 6-Dichloro-4-pyridyl isocyanate Material Safety Data Sheet
Synonym:
CAS: 159178-03-7
Section 1 - Chemical Product MSDS Name:2 6-Dichloro-4-pyridyl isocyanate Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
159178-03-7 2,6-Dichloro-4-pyridyl isocyanate unlisted
Hazard Symbols: XN
Risk Phrases: 20/21/22 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 159178-03-7: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 105 - 108 deg C @8mmHg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H2Cl2N2O
Molecular Weight: 189

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents, bases, amines, alcohols.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 159178-03-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2,6-Dichloro-4-pyridyl isocyanate - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group: II
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: II
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: II

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 159178-03-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 159178-03-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 159178-03-7 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xn:Harmful;
Risk Phrases 23/24/25-34
Safety Phrases 26-36/37/39
RIDADR UN 2206
HS Code 2933399090

 Synthetic Route

~%

2,6-dichloro-4-isocyanatopyridine Structure

2,6-dichloro-4-...

CAS#:159178-03-7

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 1 p. 309 - 312

~%

2,6-dichloro-4-isocyanatopyridine Structure

2,6-dichloro-4-...

CAS#:159178-03-7

Literature: US4308054 A1, ;

~%

2,6-dichloro-4-isocyanatopyridine Structure

2,6-dichloro-4-...

CAS#:159178-03-7

Literature: Organic Letters, , vol. 10, # 19 p. 4383 - 4386

~%

2,6-dichloro-4-isocyanatopyridine Structure

2,6-dichloro-4-...

CAS#:159178-03-7

Literature: Arkivoc, , vol. 2011, # 6 p. 92 - 119

~%

2,6-dichloro-4-isocyanatopyridine Structure

2,6-dichloro-4-...

CAS#:159178-03-7

Literature: Arkivoc, , vol. 2011, # 6 p. 92 - 119

~%

2,6-dichloro-4-isocyanatopyridine Structure

2,6-dichloro-4-...

CAS#:159178-03-7

Literature: Arkivoc, , vol. 2011, # 6 p. 92 - 119

~%

2,6-dichloro-4-isocyanatopyridine Structure

2,6-dichloro-4-...

CAS#:159178-03-7

Literature: Arkivoc, , vol. 2011, # 6 p. 92 - 119

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2,6-DICHLORO-4-PYRIDYL ISOCYANATE
4-(2,6-dichloro)pyridyl isocyanate
2,6-dichloro-4-isocyanato-pyridine
2,6-Dichloropyridin-4-yl isocyanate
2,5-DICHLOROAMYLAMINE HYDROCHLORIDE
2,6-dichloropyridin-4-isocyanate
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