GSK717
Modify Date: 2024-01-11 09:35:58
GSK717 structure
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Common Name | GSK717 | ||
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| CAS Number | 1595278-21-9 | Molecular Weight | 452.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H28N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GSK717GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1]. |
| Name | GSK717 |
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| Synonym | More Synonyms |
| Description | GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1]. |
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| Related Catalog | |
| In Vitro | GSK717 blocks synergy between NOD2 and TLR2. GSK717 does not affect NOD1, TNFR1 and TLR2-mediated responses. GSK717 (5 μM) inhibits the release of IL-8, IL-6, TNFα and IL-1β in primary human monocytes stimulated with MDP[1]. |
| References |
| Molecular Formula | C28H28N4O2 |
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| Molecular Weight | 452.55 |
| Hazard Codes | Xi |
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| MFCD32671947 |