Melagatran

Modify Date: 2024-01-02 18:11:13

Melagatran Structure
Melagatran structure
Common Name Melagatran
CAS Number 159776-70-2 Molecular Weight 429.51300
Density 1.41g/cm3 Boiling Point N/A
Molecular Formula C22H31N5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Melagatran


Melagatran is a direct and oral active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia[1]. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion[2].

 Names

Name melagatran
Synonym More Synonyms

 Melagatran Biological Activity

Description Melagatran is a direct and oral active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia[1]. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion[2].
Related Catalog
Target

Thrombin[1]

References

[1]. Eriksson M, et al. Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. Expert Opin Investig Drugs. 2000 May;9(5):1129-37.

[2]. Mehta JL, et al. Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery. J Cardiovasc Pharmacol. 1998 Mar;31(3):345-51.

 Chemical & Physical Properties

Density 1.41g/cm3
Molecular Formula C22H31N5O4
Molecular Weight 429.51300
Exact Mass 429.23800
PSA 148.61000
LogP 2.33060
Index of Refraction 1.67

 Synonyms

2-[[(1R)-2-[(2S)-2-[(4-carbamimidoylphenyl)methylcarbamoyl]azetidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]acetic acid