159776-70-2

159776-70-2 structure

Name: Melagatran
Chemical Name: melagatran
CAS Number: 159776-70-2
Molecular Formula: C₂₂H₃₁N₅O₄
Molecular Weight: 429.51300
Catalog: Signaling Pathways Metabolic Enzyme/Protease Thrombin
Create Date: 2018-09-27 11:56:47
Modify Date: 2026-07-15 18:40:01
Melagatran is a direct and oral active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia[1]. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion[2].

Name	melagatran
Synonyms	Glycine, N-[(1R)-2-[(2S)-2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl] 2-[[(1R)-2-[(2S)-2-[(4-carbamimidoylphenyl)methylcarbamoyl]azetidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]acetic acid Melagatran, 10 mM in DMSO 2-[[(1R)-2-[(2S)-2-[(4-cbamimidoylphenyl)methylcbamoyl]azetidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]acetic acid H-319/68 N-[(1R)-2-[(2S)-2-[[[[4-(Aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]glycine 2-(((R)-2-((S)-2-((4-Cbamimidoylbenzyl)cbamoyl)azetidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)acetic acid

Description	Melagatran is a direct and oral active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia[1]. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion[2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
Target	Thrombin[1]
References	[1]. Eriksson M, et al. Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. Expert Opin Investig Drugs. 2000 May;9(5):1129-37. [2]. Mehta JL, et al. Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery. J Cardiovasc Pharmacol. 1998 Mar;31(3):345-51.