Dimethoxycurcumin

Modify Date: 2024-01-09 22:47:34

Dimethoxycurcumin structure	Common Name	Dimethoxycurcumin
	CAS Number	160096-59-3	Molecular Weight	396.43
	Density	1.2±0.1 g/cm3	Boiling Point	587.0±50.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	254.4±30.2 °C

Use of Dimethoxycurcumin

Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities[1][2].

Name	Dimethoxycurcumin
Synonym	More Synonyms

Description	Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
References	[1]. Patwardhan RS, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol [2]. Pae HO, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91.

Description

Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities[1][2].

Related Catalog

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

References

[1]. Patwardhan RS, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol

[2]. Pae HO, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91.

Density	1.2±0.1 g/cm3
Boiling Point	587.0±50.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₄O₆
Molecular Weight	396.43
Flash Point	254.4±30.2 °C
Exact Mass	396.157288
PSA	71.06000
LogP	4.11
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.585

3-Buten-2-one,4...

CAS#:15001-27-1

3,4-DIMETHOXYCI...

CAS#:39856-08-1

~20%

Dimethoxycurcumin

CAS#:160096-59-3

Literature: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION; LI, Pui-Kai; LI, Chenglong; LIN, Jiayuh; FUCHS, James, R. Patent: WO2010/121007 A1, 2010 ; Location in patent: Page/Page column 6; 17-18 ;

veratraldehyde

CAS#:120-14-9

2,4-Pentandione

CAS#:123-54-6

~37%

Dimethoxycurcumin

CAS#:160096-59-3

Literature: Amolins, Michael W.; Peterson, Laura B.; Blagg, Brian S.J. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 360 - 367

Curcumin

CAS#:458-37-7

Dimethyl sulfate

CAS#:77-78-1

~70%

Dimethoxycurcumin

CAS#:160096-59-3

Literature: Mishra, Satyendra; Karmodiya, Krishanpal; Surolia, Namita; Surolia, Avadhesha Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 2894 - 2902

Curcumin

CAS#:458-37-7

methyl iodide

CAS#:74-88-4

~79%

Dimethoxycurcumin

CAS#:160096-59-3

Literature: Changtam, Chatchawan; de Koning, Harry P.; Ibrahim, Hasan; Sajid, M. Sohail; Gould, Matthew K.; Suksamrarn, Apichart European Journal of Medicinal Chemistry, 2010 , vol. 45, # 3 p. 941 - 956

veratraldehyde

CAS#:120-14-9

2,4-Pentandione

CAS#:123-54-6

~7%

N/A

CAS#:93006-00-9

Dimethoxycurcumin

CAS#:160096-59-3

Literature: Konno, Hiroyuki; Endo, Hitoshi; Ise, Satomi; Miyazaki, Keiki; Aoki, Hideo; Sanjoh, Akira; Kobayashi, Kazuya; Hattori, Yasunao; Akaji, Kenichi Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 685 - 690

Precursor 7
CAS#:15001-27-1 3-Buten-2-one,4... CAS#:39856-08-1 3,4-DIMETHOXYCI... CAS#:120-14-9 veratraldehyde CAS#:123-54-6 2,4-Pentandione
CAS#:458-37-7 Curcumin CAS#:77-78-1 Dimethyl sulfate CAS#:74-88-4 methyl iodide
DownStream 1
CAS#:52328-97-9 Tetramethylcurcumin

Di-O-methylchlordeoxydecarboxyphomazarin

4',4''-O,O-dimethylcurcumin

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-

(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione

curcumin di-O-methyl ether

di-O-methylcurcumin

1,7-Bis-(3,4-dimethoxy-phenyl)-hepta-1,6-diene-3,5-dione

(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione

Dimethylcurcumin

Dimethoxycurcumin(DiMC)

Dimethoxycurcumin

Use of Dimethoxycurcumin

Names

Dimethoxycurcumin Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms