二甲氧基姜黄素

• 常用名: 二甲氧基姜黄素
• 英文名: Dimethoxycurcumin
• CAS号: 160096-59-3
• 分子量: 396.43
• 密度: 1.2±0.1 g/cm3
• 沸点: 587.0±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₄O₆
• 熔点: N/A
• 闪点: 254.4±30.2 °C

二甲氧基姜黄素用途

二甲氧基姜黄素是姜黄素的衍生物,具有抗炎和抗氧化活性[1][2]。

二甲氧基姜黄素名称

• 中文名: 二甲氧基姜黄素
• 英文名: Dimethoxycurcumin

二甲氧基姜黄素生物活性

• 描述: 二甲氧基姜黄素是姜黄素的衍生物,具有抗炎和抗氧化活性[1][2]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Patwardhan RS, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol

  [2]. Pae HO, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91.

二甲氧基姜黄素物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 587.0±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₄O₆
• 分子量: 396.43
• 闪点: 254.4±30.2 °C
• 精确质量: 396.157288
• PSA: 71.06000
• LogP: 4.11
• InChIKey: HMJSBVCDPKODEX-NXZHAISVSA-N
• SMILES: COc1ccc(C=CC(=O)CC(=O)C=Cc2ccc(OC)c(OC)c2)cc1OC
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.585
• 储存条件: 2-8°C，保存于惰性气体中

二甲氧基姜黄素靶点实验

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实验名称：Antitrypanosomal activity against Trypanosoma brucei Lister 427 assessed as parasite ... 来源：ChEMBL 靶标：Trypanosoma brucei External Id：CHEMBL5240906

实验名称：Cytotoxicity against human HEK293 cells assessed as reduction in cell viability at 20... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL5240907

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4143590

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 15 uM after 5 h... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4143591

实验名称：Effect on firefly luciferase activity expressed in human HepG2 cells at low concentra... 来源：ChEMBL 靶标：Luciferin 4-monooxygenase External Id：CHEMBL4143592

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Ra after 24 hrs by m... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL1252095

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay 来源：ChEMBL 靶标：SK-BR-3 External Id：CHEMBL963897

实验名称：Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL963896

实验名称：Antitrypanosomal activity against multidrug-resistant Trypanosoma brucei brucei B48 a... 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL1099526

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二甲氧基姜黄素英文别名

• Di-O-methylchlordeoxydecarboxyphomazarin
• 4',4''-O,O-dimethylcurcumin
• (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione
• curcumin di-O-methyl ether
• di-O-methylcurcumin
• 1,7-Bis-(3,4-dimethoxy-phenyl)-hepta-1,6-diene-3,5-dione
• (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione
• Dimethylcurcumin
• Dimethoxycurcumin(DiMC)